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Table 2 Anthropometric and metabolic characteristics of the Stuttgart study cohort

From: Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease

 

Total

Normal weight

Overweight

Parameter

Controls

Gallstone carriers

Controls

Gallstone carriers

Controls

Gallstone carriers

Number

134

34

75

11

59

23

Age (years)

57 ± 1.1

61 ± 1.9

55 ± 1.5

63 ± 3.6

59 ± 1.4

60 ± 2.3

BMI (kg/m2)

25.2 ± 0.3

26.6 ± 0.6 α

22.7 ± 0.3

23.3 ± 0.6

28.4 ± 0.4

28.2 ± 0.6

Total cholesterol (mg/dL)

214 ± 3.7

207 ± 6.2

211 ± 4.7

214 ± 6.3

217 ± 6.0

203 ± 8.8

Total triglycerides (mg/dL)

121 ± 6.1

126 ± 7.8

101 ± 6.8

125 ± 14.2

143 ± 9.9

127 ± 9.5

Lathosterol:Cholesterol (μg/mg)

1.15 ± 0.06

1.33 ± 0.15η

0.99 ± 0.07

1.22 ± 0.26

1.33 ± 0.09δ

1.39 ± 0.18

Sitosterol:Cholesterol (μg/mg)

1.23 ± 0.06

0.97 ± 0.08 β

1.36 ± 0.09

1.11 ± 0.19

1.06 ± 0.07ε

0.90 ± 0.06

Campesterol:Cholesterol (μg/mg)

1.47 ± 0.07

1.16 ± 0.11 γ

1.67 ± 0.12

1.23 ± 0.24

1.24 ± 0.08ζ

1.12 ± 0.11

  1. BMI = body mass index.
  2. Values are given as means ± SEM (standard error of the mean).
  3. Significance between the controls and gallstone carriers was analysed with Mann–Whitney U-test (nonparametric, two-tailed).
  4. Normal weight subgroup is defined as BMI ≤ 25.4, overweight subgroup as BMI > 25.4.
  5. P-values <0.05 were considered as statistical significant.
  6. Controls vs. gallstone carriers: α P = 0.0378, β P = 0.0269 (21%), γ P = 0.0231 (21%), η (16%). No adjustment in the total group.
  7. Normal weight persons vs. overweight individuals: δ P = 0.0028 after adjustment (factor 6) P = 0.0168, ε P = 0.0044 after adjustment P = 0.0264, ζ P = 0.0065 after adjustment P = 0.039.