Influence of the polymorphism D19H on markers of cholesterol metabolism in gallstone disease. Cholesterol absorption is calculated as the ratio of sitosterol or campesterol to cholesterol (A, B), cholesterol synthesis is calculated as the ratio of lathosterol to cholesterol (C), total serum cholesterol levels mg/dL (D). Values are calculated as means ± SEM. Significance between wild type individuals and SNP carriers was analysed with Mann–Whitney U-test (nonparametric, two-tailed). P-values <0.05 were considered as statistically significant. C = control subject, GS = gallstone carrier. GG genotype (wild type individual): C = 75, GS = 14; Gc genotype (carrier of p.D19H): C = 18, GS = 11.