Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice

Table 1 Histopathological scores in mice treated with ozagrel 30 min after APAP (330 mg/kg) injection

Treatment	Histological scores (4 h after the APAP injection)
Treatment	0	1+	2+	3+	4+	5+
APAP + saline	0	0	0	2	1	2
APAP + ozagrel 100 mg/kg	2	0	2	0	0	1
APAP + ozagrel 200 mg/kg	4	1	0	0	0	0

Mice were treated with ozagrel (100 or 200 mg/kg) or saline 30 min after the APAP (330 mg/kg) injection. Hepatic sections from mice 4 h after APAP injection were scored according to severity of injury: 0, no damage; 1, only a few fields affected; 2, zonal necrosis in most fields; 3, at least 3 foci of zonal necrosis in all fields; 4, centrilobular necrosis in most lobes in all fields; 5, panlobular confluent necrosis and hemorrhaging in all fields. Values represent the total number of mice given each score (n = 5).

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