|
Treatment
|
Histological scores (4 h after the APAP injection)
|
|---|
|
0
|
1+
|
2+
|
3+
|
4+
|
5+
|
|---|
|
APAP + saline
|
0
|
0
|
0
|
2
|
1
|
2
|
|
APAP + ozagrel 100 mg/kg
|
2
|
0
|
2
|
0
|
0
|
1
|
|
APAP + ozagrel 200 mg/kg
|
4
|
1
|
0
|
0
|
0
|
0
|
- Mice were treated with ozagrel (100 or 200 mg/kg) or saline 30 min after the APAP (330 mg/kg) injection. Hepatic sections from mice 4 h after APAP injection were scored according to severity of injury: 0, no damage; 1, only a few fields affected; 2, zonal necrosis in most fields; 3, at least 3 foci of zonal necrosis in all fields; 4, centrilobular necrosis in most lobes in all fields; 5, panlobular confluent necrosis and hemorrhaging in all fields. Values represent the total number of mice given each score (n = 5).
