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Table 1 Histopathological scores in mice treated with ozagrel 30 min after APAP (330 mg/kg) injection

From: Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice

Treatment Histological scores (4 h after the APAP injection)
0 1+ 2+ 3+ 4+ 5+
APAP + saline 0 0 0 2 1 2
APAP + ozagrel 100 mg/kg 2 0 2 0 0 1
APAP + ozagrel 200 mg/kg 4 1 0 0 0 0
  1. Mice were treated with ozagrel (100 or 200 mg/kg) or saline 30 min after the APAP (330 mg/kg) injection. Hepatic sections from mice 4 h after APAP injection were scored according to severity of injury: 0, no damage; 1, only a few fields affected; 2, zonal necrosis in most fields; 3, at least 3 foci of zonal necrosis in all fields; 4, centrilobular necrosis in most lobes in all fields; 5, panlobular confluent necrosis and hemorrhaging in all fields. Values represent the total number of mice given each score (n = 5).