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Figure 1 | BMC Gastroenterology

Figure 1

From: Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice

Figure 1

Effects of ozagrel on serum ALT level and survival rate in APAP-induced liver injury. (A) Serum ALT levels 4 h after the APAP injection. Mice were treated with ozagrel (100 or 200 mg/kg), NAC (600 mg/kg) or saline 30 min after the APAP (330 mg/kg) injection. There was a significant increase in the APAP group (black bar) compared with the vehicle group (white bar). The increase in serum was significantly reduced by ozagrel (APAP + ozagrel group; gray bar) and NAC (APAP + NAC group; hatched bar). Each bar represents the mean ± S.E.M. (n = 5–7). *p < 0.01 compared with the vehicle group, # p < 0.01 compared with the APAP group. (B) Survival rate over a 48-h period in mice after APAP injection. Mice were treated with ozagrel (200 mg/kg, n=5) or saline (n=11) 30 min after the APAP (330 mg/kg, n=16) injection. A significant difference (p = 0.004) was observed between the APAP group and the APAP + ozagrel group.

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