TY - JOUR AU - Graham, G. G. AU - Scott, K. F. AU - Day, R. O. PY - 2005 DA - 2005// TI - Tolerability of paracetamol JO - Drug Saf VL - 28 UR - https://doi.org/10.2165/00002018-200528030-00004 DO - 10.2165/00002018-200528030-00004 ID - Graham2005 ER - TY - JOUR AU - Li, C. AU - Martin, B. C. PY - 2011 DA - 2011// TI - Trends in emergency department visits attributable to acetaminophen overdoses in the United States: 1993–2007 JO - Pharmacoepidemiol Drug Saf VL - 20 UR - https://doi.org/10.1002/pds.2103 DO - 10.1002/pds.2103 ID - Li2011 ER - TY - JOUR AU - Craig, D. G. AU - Bates, C. M. AU - Davidson, J. S. AU - Martin, K. G. AU - Hayes, P. C. AU - Simpson, K. J. PY - 2011 DA - 2011// TI - Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity JO - Br J Clin Pharmacol VL - 71 UR - https://doi.org/10.1111/j.1365-2125.2010.03819.x DO - 10.1111/j.1365-2125.2010.03819.x ID - Craig2011 ER - TY - JOUR AU - Gow, P. J. AU - Jones, R. M. AU - Dobson, J. L. AU - Angus, P. W. PY - 2004 DA - 2004// TI - Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit JO - J Gastroenterol Hepatol VL - 19 UR - https://doi.org/10.1111/j.1440-1746.2004.03273.x DO - 10.1111/j.1440-1746.2004.03273.x ID - Gow2004 ER - TY - JOUR AU - Wei, G. AU - Bergquist, A. AU - Broomé, U. AU - Lindgren, S. AU - Wallerstedt, S. AU - Almer, S. AU - Sangfelt, P. AU - Danielsson, A. AU - Sandberg-Gertzén, H. AU - Lööf, L. PY - 2007 DA - 2007// TI - Acute liver failure in Sweden: etiology and outcome JO - J Intern Med VL - 262 UR - https://doi.org/10.1111/j.1365-2796.2007.01818.x DO - 10.1111/j.1365-2796.2007.01818.x ID - Wei2007 ER - TY - JOUR AU - Gyamlani, G. G. AU - Parikh, C. R. PY - 2002 DA - 2002// TI - Acetaminophen toxicity: suicidal vs. accidental JO - Crit Care VL - 6 UR - https://doi.org/10.1186/cc1475 DO - 10.1186/cc1475 ID - Gyamlani2002 ER - TY - JOUR AU - Bechmann, L. P. AU - Jochum, C. AU - Kocabayoglu, P. AU - Sowa, J. P. AU - Kassalik, M. AU - Gieseler, R. K. AU - Saner, F. AU - Paul, A. AU - Trautwein, C. AU - Gerken, G. PY - 2010 DA - 2010// TI - Cytokeratin 18-based modification of the MELD score improves prediction of spontaneous survival after acute liver injury JO - J Hepatol VL - 53 UR - https://doi.org/10.1016/j.jhep.2010.04.029 DO - 10.1016/j.jhep.2010.04.029 ID - Bechmann2010 ER - TY - JOUR AU - Antoine, D. J. AU - Jenkins, R. E. AU - Dear, J. W. AU - Williams, D. P. AU - McGill, M. R. AU - Sharpe, M. R. AU - Craig, D. G. AU - Simpson, K. J. AU - Jaeschke, H. AU - Park, B. K. PY - 2012 DA - 2012// TI - Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity JO - J Hepatol VL - 56 UR - https://doi.org/10.1016/j.jhep.2011.12.019 DO - 10.1016/j.jhep.2011.12.019 ID - Antoine2012 ER - TY - JOUR AU - Raucy, J. L. AU - Lasker, J. M. AU - Lieber, C. S. AU - Black, M. PY - 1989 DA - 1989// TI - Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2 JO - Arch Biochem Biophys VL - 271 UR - https://doi.org/10.1016/0003-9861(89)90278-6 DO - 10.1016/0003-9861(89)90278-6 ID - Raucy1989 ER - TY - JOUR AU - Patten, C. J. AU - Thomas, P. E. AU - Guy, R. L. AU - Lee, M. AU - Gonzalez, F. J. AU - Guengerich, F. P. AU - Yang, C. S. PY - 1993 DA - 1993// TI - Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics JO - Chem Res Toxicol VL - 6 UR - https://doi.org/10.1021/tx00034a019 DO - 10.1021/tx00034a019 ID - Patten1993 ER - TY - JOUR AU - Lee, S. S. AU - Buters, J. T. AU - Pineau, T. AU - Fernandez-Salguero, P. AU - Gonzalez, F. J. PY - 1996 DA - 1996// TI - Role of CYP2E1 in the hepatotoxicity of acetaminophen JO - J Biol Chem VL - 271 UR - https://doi.org/10.1074/jbc.271.20.12063 DO - 10.1074/jbc.271.20.12063 ID - Lee1996 ER - TY - JOUR AU - Gonzalez, F. J. PY - 2005 DA - 2005// TI - Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1 JO - Mutat Res VL - 569 UR - https://doi.org/10.1016/j.mrfmmm.2004.04.021 DO - 10.1016/j.mrfmmm.2004.04.021 ID - Gonzalez2005 ER - TY - JOUR AU - Hanawa, N. AU - Shinohara, M. AU - Saberi, B. AU - Gaarde, W. A. AU - Han, D. AU - Kaplowitz, N. PY - 2008 DA - 2008// TI - Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury JO - J Biol Chem VL - 283 UR - https://doi.org/10.1074/jbc.M708916200 DO - 10.1074/jbc.M708916200 ID - Hanawa2008 ER - TY - JOUR AU - Hinson, J. A. AU - Pike, S. L. AU - Pumford, N. R. AU - Mayeux, P. R. PY - 1998 DA - 1998// TI - Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice JO - Chem Res Toxicol VL - 11 UR - https://doi.org/10.1021/tx9800349 DO - 10.1021/tx9800349 ID - Hinson1998 ER - TY - JOUR AU - LoGuidice, A. AU - Boelsterli, U. A. PY - 2011 DA - 2011// TI - Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition JO - Hepatology VL - 54 UR - https://doi.org/10.1002/hep.24464 DO - 10.1002/hep.24464 ID - LoGuidice2011 ER - TY - JOUR AU - James, L. P. AU - McCullough, S. S. AU - Lamps, L. W. AU - Hinson, J. A. PY - 2003 DA - 2003// TI - Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation JO - Toxicol Sci VL - 75 UR - https://doi.org/10.1093/toxsci/kfg181 DO - 10.1093/toxsci/kfg181 ID - James2003 ER - TY - JOUR AU - Masubuchi, Y. AU - Suda, C. AU - Horie, T. PY - 2005 DA - 2005// TI - Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice JO - J Hepatol VL - 42 UR - https://doi.org/10.1016/j.jhep.2004.09.015 DO - 10.1016/j.jhep.2004.09.015 ID - Masubuchi2005 ER - TY - JOUR AU - Masubuchi, Y. AU - Sugiyama, S. AU - Horie, T. PY - 2009 DA - 2009// TI - Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury JO - Chem Biol Interact VL - 179 UR - https://doi.org/10.1016/j.cbi.2008.10.028 DO - 10.1016/j.cbi.2008.10.028 ID - Masubuchi2009 ER - TY - JOUR AU - Jaeschke, H. AU - Williams, C. D. AU - Ramachandran, A. AU - Bajt, M. L. PY - 2012 DA - 2012// TI - Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity JO - Liver Int VL - 32 UR - https://doi.org/10.1111/j.1478-3231.2011.02501.x DO - 10.1111/j.1478-3231.2011.02501.x ID - Jaeschke2012 ER - TY - JOUR AU - Culo, F. AU - Renić, M. AU - Sabolović, D. AU - Rados, M. AU - Bilić, A. AU - Jagić, V. PY - 1995 DA - 1995// TI - Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice JO - Eur J Gastroenterol Hepatol VL - 7 ID - Culo1995 ER - TY - JOUR AU - North, T. E. AU - Babu, I. R. AU - Vedder, L. M. AU - Lord, A. M. AU - Wishnok, J. S. AU - Tannenbaum, S. R. AU - Zon, L. I. AU - Goessling, W. PY - 2010 DA - 2010// TI - PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury JO - Proc Natl Acad Sci USA VL - 107 UR - https://doi.org/10.1073/pnas.1008209107 DO - 10.1073/pnas.1008209107 ID - North2010 ER - TY - JOUR AU - Rolin, S. AU - Masereel, B. AU - Dogné, J. M. PY - 2006 DA - 2006// TI - Prostanoids as pharmacological targets in COPD and asthma JO - Eur J Pharmacol VL - 533 UR - https://doi.org/10.1016/j.ejphar.2005.12.058 DO - 10.1016/j.ejphar.2005.12.058 ID - Rolin2006 ER - TY - JOUR AU - Ishitsuka, Y. AU - Moriuchi, H. AU - Isohama, Y. AU - Tokunaga, H. AU - Hatamoto, K. AU - Kurita, S. AU - Irikura, M. AU - Iyama, K. AU - Irie, T. PY - 2009 DA - 2009// TI - A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs JO - J Pharmacol Sci VL - 111 UR - https://doi.org/10.1254/jphs.09128SC DO - 10.1254/jphs.09128SC ID - Ishitsuka2009 ER - TY - JOUR AU - Xavier, F. E. AU - Blanco-Rivero, J. AU - Sastre, E. AU - Badimón, L. AU - Balfagón, G. PY - 2010 DA - 2010// TI - Simultaneous inhibition of TXA(2) and PGI(2) synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats JO - Clin Sci (Lond) VL - 119 UR - https://doi.org/10.1042/CS20090536 DO - 10.1042/CS20090536 ID - Xavier2010 ER - TY - JOUR AU - Watson, S. AU - Daly, M. AU - Dawood, B. AU - Gissen, P. AU - Makris, M. AU - Mundell, S. AU - Wilde, J. AU - Mumford, A. PY - 2010 DA - 2010// TI - Phenotypic approaches to gene mapping in platelet function disorders - identification of new variant of P2Y12, TxA2 and GPVI receptors JO - Hämostaseologie VL - 30 ID - Watson2010 ER - TY - JOUR AU - Cavar, I. AU - Kelava, T. AU - Vukojević, K. AU - Saraga-Babić, M. AU - Culo, F. PY - 2010 DA - 2010// TI - The role of prostaglandin E2 in acute acetaminophen hepatotoxicity in mice JO - Histol Histopathol VL - 25 ID - Cavar2010 ER - TY - JOUR AU - Cavar, I. AU - Kelava, T. AU - Heinzel, R. AU - Culo, F. PY - 2009 DA - 2009// TI - The role of prostacyclin in modifying acute hepatotoxicity of acetaminophen in mice JO - Coll Antropol VL - 33 ID - Cavar2009 ER - TY - JOUR AU - Reilly, T. P. AU - Brady, J. N. AU - Marchick, M. R. AU - Bourdi, M. AU - George, J. W. AU - Radonovich, M. F. AU - Pise-Masison, C. A. AU - Pohl, L. R. PY - 2001 DA - 2001// TI - A protective role for cyclooxygenase-2 in drug-induced liver injury in mice JO - Chem Res Toxicol VL - 14 UR - https://doi.org/10.1021/tx0155505 DO - 10.1021/tx0155505 ID - Reilly2001 ER - TY - JOUR AU - Guarner, F. AU - Boughton-Smith, N. K. AU - Blackwell, G. J. AU - Moncada, S. PY - 1988 DA - 1988// TI - Reduction by prostacyclin of acetaminophen-induced liver toxicity in the mouse JO - Hepatology VL - 8 UR - https://doi.org/10.1002/hep.1840080210 DO - 10.1002/hep.1840080210 ID - Guarner1988 ER - TY - JOUR AU - Baciewicz, A. M. AU - Baciewicz, F. A. PY - 1993 DA - 1993// TI - Ketoconazole and fluconazole drug interactions JO - Arch Intern Med VL - 153 UR - https://doi.org/10.1001/archinte.1993.00410170042004 DO - 10.1001/archinte.1993.00410170042004 ID - Baciewicz1993 ER - TY - JOUR AU - Nakazawa, M. AU - Iizuka, K. AU - Ujiie, A. AU - Hiraku, S. AU - Ohki, S. PY - 1994 DA - 1994// TI - [Research and development of ozagrel, a highly selective inhibitor of TXA2 synthase] JO - Yakugaku Zasshi VL - 114 ID - Nakazawa1994 ER - TY - JOUR AU - Dogné, J. M. AU - de Leval, X. AU - Benoit, P. AU - Delarge, J. AU - Masereel, B. PY - 2002 DA - 2002// TI - Thromboxane A2 inhibition: therapeutic potential in bronchial asthma JO - Am J Respir Med VL - 1 UR - https://doi.org/10.1007/BF03257158 DO - 10.1007/BF03257158 ID - Dogné2002 ER - TY - JOUR AU - Ishitsuka, Y. AU - Moriuchi, H. AU - Hatamoto, K. AU - Yang, C. AU - Takase, J. AU - Golbidi, S. AU - Irikura, M. AU - Irie, T. PY - 2004 DA - 2004// TI - Involvement of thromboxane A2 (TXA2) in the early stages of oleic acid-induced lung injury and the preventive effect of ozagrel, a TXA2 synthase inhibitor, in guinea-pigs JO - J Pharm Pharmacol VL - 56 UR - https://doi.org/10.1211/0022357023150 DO - 10.1211/0022357023150 ID - Ishitsuka2004 ER - TY - JOUR AU - Matsunaga, N. AU - Nakamura, N. AU - Yoneda, N. AU - Qin, T. AU - Terazono, H. AU - To, H. AU - Higuchi, S. AU - Ohdo, S. PY - 2004 DA - 2004// TI - Influence of feeding schedule on 24-h rhythm of hepatotoxicity induced by acetaminophen in mice JO - J Pharmacol Exp Ther VL - 311 UR - https://doi.org/10.1124/jpet.104.069062 DO - 10.1124/jpet.104.069062 ID - Matsunaga2004 ER - TY - JOUR AU - Latchoumycandane, C. AU - Goh, C. W. AU - Ong, M. M. AU - Boelsterli, U. A. PY - 2007 DA - 2007// TI - Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury JO - Hepatology VL - 45 UR - https://doi.org/10.1002/hep.21475 DO - 10.1002/hep.21475 ID - Latchoumycandane2007 ER - TY - JOUR AU - Reisman, S. A. AU - Buckley, D. B. AU - Tanaka, Y. AU - Klaassen, C. D. PY - 2009 DA - 2009// TI - CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes JO - Toxicol Appl Pharmacol VL - 236 UR - https://doi.org/10.1016/j.taap.2008.12.024 DO - 10.1016/j.taap.2008.12.024 ID - Reisman2009 ER - TY - JOUR AU - Omura, T. AU - Sato, R. PY - 1964 DA - 1964// TI - The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature JO - J Biol Chem VL - 239 ID - Omura1964 ER - TY - JOUR AU - Kondo, Y. AU - Ishitsuka, Y. AU - Kadowaki, D. AU - Nagatome, M. AU - Saisho, Y. AU - Kuroda, M. AU - Hirata, S. AU - Irikura, M. AU - Hamasaki, N. AU - Irie, T. PY - 2010 DA - 2010// TI - Phosphoenolpyruvic acid, an intermediate of glycolysis, attenuates cellular injury induced by hydrogen peroxide and 2-deoxy-D-glucose in the porcine proximal kidney tubular cell line, LLC-PK 1 JO - J Heal Sci VL - 56 UR - https://doi.org/10.1248/jhs.56.727 DO - 10.1248/jhs.56.727 ID - Kondo2010 ER - TY - JOUR AU - Kondo, Y. AU - Ishitsuka, Y. AU - Kadowaki, D. AU - Kuroda, M. AU - Tanaka, Y. AU - Nagatome, M. AU - Irikura, M. AU - Hirata, S. AU - Sato, K. AU - Maruyama, T. PY - 2012 DA - 2012// TI - Phosphoenolpyruvic acid, an intermediary metabolite of glycolysis, as a potential cytoprotectant and anti-oxidant in HeLa cells JO - Biol Pharm Bull VL - 35 UR - https://doi.org/10.1248/bpb.35.606 DO - 10.1248/bpb.35.606 ID - Kondo2012 ER - TY - JOUR AU - Yoshimi, Y. AU - Fujimura, M. AU - Myou, S. AU - Tachibana, H. AU - Hirose, T. PY - 2001 DA - 2001// TI - Effect of thromboxane A2 (TXA2) synthase inhibitor and TXA2 receptor antagonist alone and in combination on antigen-induced bronchoconstriction in guinea pigs JO - Prostaglandins Other Lipid Mediat VL - 65 UR - https://doi.org/10.1016/S0090-6980(01)00099-5 DO - 10.1016/S0090-6980(01)00099-5 ID - Yoshimi2001 ER - TY - JOUR AU - Sasaki, K. AU - Miyake, H. AU - Kinoshita, T. AU - Ikeyama, S. AU - Tashiro, S. PY - 2004 DA - 2004// TI - Protective effect of FK506 and thromboxane synthase inhibitor on ischemia-reperfusion injury in non-heart-beating donor in rat orthotopic liver transplantation JO - J Med Invest VL - 51 UR - https://doi.org/10.2152/jmi.51.76 DO - 10.2152/jmi.51.76 ID - Sasaki2004 ER - TY - JOUR AU - Xu, H. AU - Lee, C. Y. AU - Clemens, M. G. AU - Zhang, J. X. PY - 2008 DA - 2008// TI - Inhibition of TXA synthesis with OKY-046 improves liver preservation by prolonged hypothermic machine perfusion in rats JO - J Gastroenterol Hepatol VL - 23 UR - https://doi.org/10.1111/j.1440-1746.2007.05061.x DO - 10.1111/j.1440-1746.2007.05061.x ID - Xu2008 ER - TY - JOUR AU - Beyer, R. P. AU - Fry, R. C. AU - Lasarev, M. R. AU - McConnachie, L. A. AU - Meira, L. B. AU - Palmer, V. S. AU - Powell, C. L. AU - Ross, P. K. AU - Bammler, T. K. AU - Bradford, B. U. PY - 2007 DA - 2007// TI - Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses JO - Toxicol Sci VL - 99 UR - https://doi.org/10.1093/toxsci/kfm150 DO - 10.1093/toxsci/kfm150 ID - Beyer2007 ER - TY - JOUR AU - Nakagawa, H. AU - Maeda, S. AU - Hikiba, Y. AU - Ohmae, T. AU - Shibata, W. AU - Yanai, A. AU - Sakamoto, K. AU - Ogura, K. AU - Noguchi, T. AU - Karin, M. PY - 2008 DA - 2008// TI - Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation JO - Gastroenterology VL - 135 UR - https://doi.org/10.1053/j.gastro.2008.07.006 DO - 10.1053/j.gastro.2008.07.006 ID - Nakagawa2008 ER - TY - JOUR AU - Nagy, G. AU - Kardon, T. AU - Wunderlich, L. AU - Szarka, A. AU - Kiss, A. AU - Schaff, Z. AU - Bánhegyi, G. AU - Mandl, J. PY - 2007 DA - 2007// TI - Acetaminophen induces ER dependent signaling in mouse liver JO - Arch Biochem Biophys VL - 459 UR - https://doi.org/10.1016/j.abb.2006.11.021 DO - 10.1016/j.abb.2006.11.021 ID - Nagy2007 ER - TY - JOUR AU - Badmann, A. AU - Keough, A. AU - Kaufmann, T. AU - Bouillet, P. AU - Brunner, T. AU - Corazza, N. PY - 2011 DA - 2011// TI - Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage JO - Cell Death Dis VL - 2 UR - https://doi.org/10.1038/cddis.2011.55 DO - 10.1038/cddis.2011.55 ID - Badmann2011 ER - TY - JOUR AU - Wiggins, C. M. AU - Tsvetkov, P. AU - Johnson, M. AU - Joyce, C. L. AU - Lamb, C. A. AU - Bryant, N. J. AU - Komander, D. AU - Shaul, Y. AU - Cook, S. J. PY - 2011 DA - 2011// TI - BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation JO - J Cell Sci VL - 124 UR - https://doi.org/10.1242/jcs.058438 DO - 10.1242/jcs.058438 ID - Wiggins2011 ER - TY - JOUR AU - Hinds, M. G. AU - Smits, C. AU - Fredericks-Short, R. AU - Risk, J. M. AU - Bailey, M. AU - Huang, D. C. AU - Day, C. L. PY - 2007 DA - 2007// TI - Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets JO - Cell Death Differ VL - 14 UR - https://doi.org/10.1038/sj.cdd.4401934 DO - 10.1038/sj.cdd.4401934 ID - Hinds2007 ER - TY - JOUR AU - Bantel, H. AU - Schulze-Osthoff, K. PY - 2012 DA - 2012// TI - Mechanisms of cell death in acute liver failure JO - Front Physiol VL - 3 UR - https://doi.org/10.3389/fphys.2012.00079 DO - 10.3389/fphys.2012.00079 ID - Bantel2012 ER - TY - JOUR AU - Saito, C. AU - Zwingmann, C. AU - Jaeschke, H. PY - 2010 DA - 2010// TI - Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine JO - Hepatology VL - 51 UR - https://doi.org/10.1002/hep.23267 DO - 10.1002/hep.23267 ID - Saito2010 ER - TY - JOUR AU - Gunawan, B. K. AU - Liu, Z. X. AU - Han, D. AU - Hanawa, N. AU - Gaarde, W. A. AU - Kaplowitz, N. PY - 2006 DA - 2006// TI - c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity JO - Gastroenterology VL - 131 UR - https://doi.org/10.1053/j.gastro.2006.03.045 DO - 10.1053/j.gastro.2006.03.045 ID - Gunawan2006 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/13/21/prepub UR - http://www.biomedcentral.com/1471-230X/13/21/prepub ID - ref52 ER -