Table 2 Intraluminal and Intraperitoneal sensitivity, specificity, threshold and AUC - values for detecting ischemia in human gut by lactate to pyruvate ratio, glycerol and lactate to glucose ratio
From: Validation of Intraluminal and Intraperitoneal microdialysis in ischemic small intestine
Intraluminal | Intraperitoneal | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Minutes after ischemia | Minutes after ischemia | ||||||||
1–30 | Threshold level | Sensitivity | Specificity | AUC* | 1–30 | Threshold level | Sensitivity | Specificity | AUC* |
18.95 | 73.30% | 63% | |||||||
L/P | 22.35 | 70.00% | 66.70% | L/P | 15.37 | 63.00% | 56.40% | ||
28.79 | 66.70% | 66.70% | 0.695 | 18.59 | 60.90% | 79.50% | 0.673 | ||
19.54 | 58.70% | 79.50% | |||||||
Glycerol μmol/l | 19.78 | 67.50% | 60.90% | Glycerol μmol/l | 100.61 | 68.10% | 48.90% | ||
20.07 | 65.00% | 60.90% | 0.701 | 108.70 | 66.00% | 55.30% | 0.584 | ||
20.49 | 65.00% | 63.00% | 114.73 | 57.40% | 57.40% | ||||
L/G | 1.75 | 73.90% | 39.30% | L/G | 0.38 | 70.80% | 79.10% | ||
3.75 | 60.90% | 60.70% | 0.634 | 0.41 | 68.80% | 81.40% | 0.78 | ||
7.59 | 43.50% | 67.90% | 0.44 | 64.60% | 81.40% | ||||
Minutes after ischemia | Minutes after ischemia | ||||||||
31–60 | Threshold level | Sensitivity | Specificity | AUC | 31–60 | Threshold level | Sensitivity | Specificity | AUC |
L/P | 68.49 | 96.00% | 85.20% | L/P | 31.27 | 76.90% | 92.30% | ||
109.42 | 96.00% | 88.90% | 0.954 | 35.95 | 76.90% | 94.90% | 0.800 | ||
137.51 | 92.00% | 88.90% | 37.72 | 74.40% | 94.90% | ||||
Glycerol μmol/l | 58.27 | 87.00% | 89.10% | Glycerol μmol/l | 103.22 | 62.20% | 51.10% | ||
68.71 | 87.00% | 91.30% | 0.903 | 108.92 | 60.00% | 55.30% | 0.593 | ||
79.13 | 85.20% | 91.30% | 114.52 | 53.30% | 57.40% | ||||
L/G | 40.50 | 88.90% | 92.90% | L/G | 0.76 | 89.50% | 90.70% | ||
48.90 | 88.90% | 96.40% | 0.956 | 0.95 | 89.50% | 93.00% | 0.94 | ||
57.40 | 85.20% | 96.40% | 1.04 | 86.80% | 93.00% | ||||
Minutes after ischemia | Minutes after ischemia | ||||||||
61–90 | Threshold level | Sensitivity | Specificity | AUC | 61–90 | Threshold level | Sensitivity | Specificity | AUC |
L/P | 52.77 | 100.00% | 81.50% | L/P | 18.27 | 96.60% | 79.50% | ||
68.49 | 100.00% | 85.20% | 0.996 | 23.87 | 93.10% | 87.20% | 0.938 | ||
131.40 | 100.00% | 88.90% | 31.27 | 89.70% | 92.30% | ||||
Glycerol μmol/l | 28.82 | 80.40% | 67.40% | Glycerol μmol/l | 102.02 | 74.30% | 48.90% | ||
39.02 | 80.40% | 80.40% | 0.897 | 116.69 | 71.40% | 61.70% | 0.700 | ||
58.27 | 80.40% | 88.10% | 125.57 | 62.90% | 66.00% | ||||
L/G | 36.50 | 88.50% | 89.30% | L/G | 0.46 | 95.20% | 81.40% | ||
46.50 | 88.50% | 96.40% | 0.974 | 0.76 | 95.20% | 91.70% | 0.97 | ||
58.40 | 80.80% | 100.00% | 1.97 | 95.20% | 93% | ||||
Minutes after ischemia | Minutes after ischemia | ||||||||
91–120 | Threshold level | Sensitivity | Specificity | AUC | 91–120 | Threshold level | Sensitivity | Specificity | AUC |
L/P | 27.78 | 100.00% | 66.70% | L/P | 19.11 | 85.70% | 79.50% | ||
41.13 | 100.00% | 70.40% | 0.989 | 27.17 | 85.70% | 89.70% | 0.860 | ||
52.77 | 100.00% | 81.50% | 31.22 | 75.00% | 92.30% | ||||
Glycerol μmol/l | 40.47 | 92.70% | 82.60% | Glycerol μmol/l | 115.61 | 76.50% | 59.60% | ||
49.55 | 92.70% | 87.00% | 0.950 | 122.43 | 76.50% | 63.80% | 0.791 | ||
58.27 | 92.70% | 89.10% | 145.27 | 70.60% | 76.60% | ||||
L/G | 28.50 | 95.20% | 85.70% | L/G | 0.46 | 100.00% | 81.40% | ||
36.50 | 95.20% | 89.30% | 0.971 | 1.97 | 100.00% | 93.00% | 0.99 | ||
47.50 | 95.20% | 96.40% | 5 | 100% | 97.7 % |