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Table 2 Intraluminal and Intraperitoneal sensitivity, specificity, threshold and AUC - values for detecting ischemia in human gut by lactate to pyruvate ratio, glycerol and lactate to glucose ratio

From: Validation of Intraluminal and Intraperitoneal microdialysis in ischemic small intestine

  Intraluminal      Intraperitoneal    
Minutes after ischemia      Minutes after ischemia     
1–30 Threshold level Sensitivity Specificity AUC* 1–30 Threshold level Sensitivity Specificity AUC*
  18.95 73.30% 63%       
L/P 22.35 70.00% 66.70%   L/P 15.37 63.00% 56.40%  
  28.79 66.70% 66.70% 0.695   18.59 60.90% 79.50% 0.673
       19.54 58.70% 79.50%  
Glycerol μmol/l 19.78 67.50% 60.90%   Glycerol μmol/l 100.61 68.10% 48.90%  
  20.07 65.00% 60.90% 0.701   108.70 66.00% 55.30% 0.584
  20.49 65.00% 63.00%    114.73 57.40% 57.40%  
L/G 1.75 73.90% 39.30%   L/G 0.38 70.80% 79.10%  
  3.75 60.90% 60.70% 0.634   0.41 68.80% 81.40% 0.78
  7.59 43.50% 67.90%    0.44 64.60% 81.40%  
Minutes after ischemia      Minutes after ischemia     
31–60 Threshold level Sensitivity Specificity AUC 31–60 Threshold level Sensitivity Specificity AUC
L/P 68.49 96.00% 85.20%   L/P 31.27 76.90% 92.30%  
  109.42 96.00% 88.90% 0.954   35.95 76.90% 94.90% 0.800
  137.51 92.00% 88.90%    37.72 74.40% 94.90%  
Glycerol μmol/l 58.27 87.00% 89.10%   Glycerol μmol/l 103.22 62.20% 51.10%  
  68.71 87.00% 91.30% 0.903   108.92 60.00% 55.30% 0.593
  79.13 85.20% 91.30%    114.52 53.30% 57.40%  
L/G 40.50 88.90% 92.90%   L/G 0.76 89.50% 90.70%  
  48.90 88.90% 96.40% 0.956   0.95 89.50% 93.00% 0.94
  57.40 85.20% 96.40%    1.04 86.80% 93.00%  
Minutes after ischemia      Minutes after ischemia     
61–90 Threshold level Sensitivity Specificity AUC 61–90 Threshold level Sensitivity Specificity AUC
L/P 52.77 100.00% 81.50%   L/P 18.27 96.60% 79.50%  
  68.49 100.00% 85.20% 0.996   23.87 93.10% 87.20% 0.938
  131.40 100.00% 88.90%    31.27 89.70% 92.30%  
Glycerol μmol/l 28.82 80.40% 67.40%   Glycerol μmol/l 102.02 74.30% 48.90%  
  39.02 80.40% 80.40% 0.897   116.69 71.40% 61.70% 0.700
  58.27 80.40% 88.10%    125.57 62.90% 66.00%  
L/G 36.50 88.50% 89.30%   L/G 0.46 95.20% 81.40%  
  46.50 88.50% 96.40% 0.974   0.76 95.20% 91.70% 0.97
  58.40 80.80% 100.00%    1.97 95.20% 93%  
Minutes after ischemia      Minutes after ischemia     
91–120 Threshold level Sensitivity Specificity AUC 91–120 Threshold level Sensitivity Specificity AUC
L/P 27.78 100.00% 66.70%   L/P 19.11 85.70% 79.50%  
  41.13 100.00% 70.40% 0.989   27.17 85.70% 89.70% 0.860
  52.77 100.00% 81.50%    31.22 75.00% 92.30%  
Glycerol μmol/l 40.47 92.70% 82.60%   Glycerol μmol/l 115.61 76.50% 59.60%  
  49.55 92.70% 87.00% 0.950   122.43 76.50% 63.80% 0.791
  58.27 92.70% 89.10%    145.27 70.60% 76.60%  
L/G 28.50 95.20% 85.70%   L/G 0.46 100.00% 81.40%  
  36.50 95.20% 89.30% 0.971   1.97 100.00% 93.00% 0.99
  47.50 95.20% 96.40%    5 100% 97.7 %  
  1. *AUC, area under the curve in receiver operating characteristics (ROC) analysis.