Event | Definition |
---|---|
Organ failure | Organ failure is defined as: |
• Cardiovascular: systolic blood pressure < 90 mmHg despite adequate fluid resuscitation or need for vasopressor support | |
• Pulmonary: PaO2 < 60 mmHg despite FiO2 30%, or the need for mechanical ventilation; | |
• Renal: serum creatinine > 177 mmol/L after rehydration or need for hemofiltration or hemodialysis; | |
Definitions are adapted from the Atlanta classification and the same as previously used in the PANTER trial [2] | |
New onset organ failure | Organ failure occurring after randomisation and not present 24Â hours before randomisation |
Multiple organ failure | Failure of 2 or more organ systems on the same day |
Enterocutaneous fistula | Enterocutaneous fistula is defined as secretion of fecal material from a percutaneous drain, drainage canal after removal of drains, or from a surgical wound, either from small or large bowel; confirmed by imaging or during surgery [2] |
Incisional hernia | Incisional hernia is defined as a full-thickness discontinuity of the abdominal wall and bulging of abdominal contents, with or without obstruction [2] |