Figure 7
From: Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity
UDCA treatment preserves PAS-positive collagen aggregates in the liver with acute cholestasis. (A) Tissue sections of liver isolated from sham-operated animals treated with vehicle only (SHAM), sham-operated animals treated with UDCA (SHAM UDCA), animals with ligated bile ducts treated with vehicle only (BDL), and animals with ligated bile ducts treated with UDCA (BDL UDCA) were stained with PAS for glycogen storage in hepatocytes. Bar, 50 μm. (B) Intensity of PAS reaction was semiquantitatively evaluated and normalized as described in the text; >80 cells per field from more than five randomly chosen optical fields of each dissected liver. Mean values ± SEM are shown (n = 4). ***p < 0.001.