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Table 4 Tumor board review of H&N cancer patients with modified treatment strategy after IEE screening

From: Risk factors for second primary neoplasia of esophagus in newly diagnosed head and neck cancer patients: a case–control study

No.

H&N cancer / TNM stage

Location / size (cm) / pathology (TNM stage) of esophagus

Treatment strategy without IEE screening

Treatment strategy with IEE screening

1

Oropharynx / II

Lower third / 0.3 / LGIN

Tumor excision

Tumor excision + EMR of esophageal lesion

2

Hypopharynx / I

Middle third / 0.5 / LGIN

Tumor excision

Tumor excision + EMR of esophageal lesion

3

Oropharynx / III

Lower third / 0.5 / LGIN

Tumor excision + LN dissection + Adjuvant CCRT

Tumor excision + EMR of esophageal lesion + Adjuvant CCRT

4

Hypopharynx / III

Middle third / 6.0 / SCC (IIA)

Tumor excision + LN dissection + Adjuvant CCRT

Tumor excision + Adjuvant CCRT with RT field involving esophagus

5

Larynx / I

Middle / 1.5 / HGIN

Laryngectomy

Laryngectomy + ESD of esophageal lesion

6

Larynx / I

Upper / 6.0 / SCC (IB)

Laryngectomy

Laryngectomy + Esophagectomy + Adjuvant CCRT

7

Oropharynx / IVA

Upper / 0.6 / SCC (IA)

Neoadjuvant CCRT + Tumor excision + LN dissection

Neoadjuvant CCRT + Tumor excision + Esophagectomy

8

Oropharynx / II

Middle / 4.0 / SCC (IA)

Tumor excision + Adjuvant CCRT

Tumor excision + Esophagectomy + Adjuvant CCRT

9

Hypopharynx/IVA

Middle / 2.0 / HGIN

Tumor excision + LN dissection + Adjuvant CCRT

Tumor excision + LN dissection + RFA of esophageal lesion + Adjuvant CCRT

10

Hypopharynx / IVB

Upper / 1.5 / SCC(IB)

Definitive CCRT

Definitive CCRT with RT field involving the esophagus

11

Hypopharynx/III

Middle / 5.0 / SCC (IIIA)

Tumor excision + LN dissection + Adjuvant CCRT

Neoadjuvant CCRT + Tumor excision + LN dissection + Esophagectomy

12

Hypopharynx / IVB

Middle / 1.5 / SCC (IIIA)

Definitive CCRT

Definitive CCRT with RT filed involving the esophagus

13

Oral cavity / II

Lower / 0.2 / LGIN

Tumor excision

Tumor excision + EMR of esophageal lesion

14

Hypopharynx / III

Middle / 0.8 / HGIN

Tumor excision + LN dissection + Adjuvant CCRT

Tumor excision + LN dissection + ESD of esophageal lesion + Adjuvant CCRT

15

Oral cavity / I

Upper / 2.0 / SCC ( IB)

Tumor excision

Tumor excision + Esophagectomy

16

Oral cavity / II

Middle / 1.0 / SCC (IA)

Tumor excision

Tumor excision + EMR of esophageal lesion

17

Oral cavity / IVB

Middle / 2.0 / SCC (IIIA)

Definitive CCRT

Definitive CCRT with RT field involving esophagus

18

Hypopharynx / IVA

Upper / 2.0 / SCC (IB)

Tumor excision + LN dissection + Adjuvant CCRT

Tumor excision + LN dissection + Adjuvant CCRT with RT field involving esophagus

19

Hypopharynx / IVA

Middle / 0.8 / HGIN

Tumor excision + LN dissection + Adjuvant CCRT

Tumor excision + LN dissection + EMR + Adjuvant CCRT

20

Larynx / IVA

Middle / 6.0 / SCC (IB)

Laryngectomy + Adjuvant CCRT

Laryngectomy + Esophagectomy + Adjuvant CCRT

  1. Abbreviation: CCRT concurrent chemoradiotherapy, EMR endoscopic mucosal resection, ESD endoscopic submucosal dissection, H&N head and neck, HGIN high-grade intraepithelial neoplasia, IEE image-enhanced endoscopy, LN lymph node, LGIN low-grade intraepithelial neoplasia, RFA radiofrequency ablation, SCC squamous cell carcinoma.