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Table 1 MYC , FBXW7 and TP53 gene copy number variation, MYC and p53 protein expression and clinicopathological features of 33 GC patients

From: MYC, FBXW7 and TP53 copy number variation and expression in Gastric Cancer

  CNV MYC CNV FBXW7   CNV TP53   IHC MYC IHC p53
  2 copies (n = 16) ≥ 3 copies (n = 17) p- value 2 copies (n = 18) 1 copy (n = 15) p- value 2 copies (n = 25) 1 copy (n = 7) p- value P (n = 19) N (n = 14) p- value P (n = 6) N (n = 25) p- value
Age (y) (mean ± SD)
>50 (65.3 ± 9.1) 7 12 0.166 12 7 0.304 15 3 0.393 10 4 0.310 5 9 0.094
≤50 (42.1 ± 8.2) 9 5   6 8   10 4   10 9   2 17  
Gender
Male 8 7 0.437 7 8 1.000 13 1 0.104 12 3 0.072 2 13 0.413
Female 8 10   8 10   12 6   8 10   5 13  
Histopathology
Intestinal 12 10 0.465 12 10 1.000 16 6 0.387 17 5 0.009* 6 16 0.378
Diffuse 4 7   6 5   9 1   3 8   1 10  
Depth of tumor invasion
T1 3 3 1.000 5 1 0.186 5 1 1.000 2 4 0.182 1 5 1.000
T2-T4 13 14   13 14   20 6   18 9   6 21  
Lymph node metastasis
Absent 5 8 0.481 8 5 0.722 10 3 1.000 7 6 0.717 2 11 0.676
Present 11 9   10 10   15 4   13 7   5 15  
Stage
I-II 8 10 0.732 12 6 0.170 14 3 0.678 12 6 0.493 3 15 0.674
III-IV 8 7   6 9   11 4   8 7   4 11  
MYC IHC
Negative 5 8 0.481 7 6 1.000 11 2 0.671       
Positive 11 9   11 9   14 5        
p53 IHC
Negative 14 12 0.398 14 12 1.000 21 4 0.157       
Positive 2 5   4 3   4 3        
  1. *p < 0.05; P: positive; N: negative.