From: MYC, FBXW7 and TP53 copy number variation and expression in Gastric Cancer
CNV MYC | CNV FBXW7 | CNV TP53 | IHC MYC | IHC p53 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2 copies (n = 16) | ≥ 3 copies (n = 17) | p- value | 2 copies (n = 18) | 1 copy (n = 15) | p- value | 2 copies (n = 25) | 1 copy (n = 7) | p- value | P (n = 19) | N (n = 14) | p- value | P (n = 6) | N (n = 25) | p- value | |
Age (y) (mean ± SD) | |||||||||||||||
>50 (65.3 ± 9.1) | 7 | 12 | 0.166 | 12 | 7 | 0.304 | 15 | 3 | 0.393 | 10 | 4 | 0.310 | 5 | 9 | 0.094 |
≤50 (42.1 ± 8.2) | 9 | 5 | 6 | 8 | 10 | 4 | 10 | 9 | 2 | 17 | |||||
Gender | |||||||||||||||
Male | 8 | 7 | 0.437 | 7 | 8 | 1.000 | 13 | 1 | 0.104 | 12 | 3 | 0.072 | 2 | 13 | 0.413 |
Female | 8 | 10 | 8 | 10 | 12 | 6 | 8 | 10 | 5 | 13 | |||||
Histopathology | |||||||||||||||
Intestinal | 12 | 10 | 0.465 | 12 | 10 | 1.000 | 16 | 6 | 0.387 | 17 | 5 | 0.009* | 6 | 16 | 0.378 |
Diffuse | 4 | 7 | 6 | 5 | 9 | 1 | 3 | 8 | 1 | 10 | |||||
Depth of tumor invasion | |||||||||||||||
T1 | 3 | 3 | 1.000 | 5 | 1 | 0.186 | 5 | 1 | 1.000 | 2 | 4 | 0.182 | 1 | 5 | 1.000 |
T2-T4 | 13 | 14 | 13 | 14 | 20 | 6 | 18 | 9 | 6 | 21 | |||||
Lymph node metastasis | |||||||||||||||
Absent | 5 | 8 | 0.481 | 8 | 5 | 0.722 | 10 | 3 | 1.000 | 7 | 6 | 0.717 | 2 | 11 | 0.676 |
Present | 11 | 9 | 10 | 10 | 15 | 4 | 13 | 7 | 5 | 15 | |||||
Stage | |||||||||||||||
I-II | 8 | 10 | 0.732 | 12 | 6 | 0.170 | 14 | 3 | 0.678 | 12 | 6 | 0.493 | 3 | 15 | 0.674 |
III-IV | 8 | 7 | 6 | 9 | 11 | 4 | 8 | 7 | 4 | 11 | |||||
MYC IHC | |||||||||||||||
Negative | 5 | 8 | 0.481 | 7 | 6 | 1.000 | 11 | 2 | 0.671 | ||||||
Positive | 11 | 9 | 11 | 9 | 14 | 5 | |||||||||
p53 IHC | |||||||||||||||
Negative | 14 | 12 | 0.398 | 14 | 12 | 1.000 | 21 | 4 | 0.157 | ||||||
Positive | 2 | 5 | 4 | 3 | 4 | 3 |