Figure 6

Dissemination of C. rodentium from the intestine causes liver injury in GC-C ^−/− mice at day 10 following infection. A: In colonized mice, GC-C^−/− livers had significantly more C. rodentium CFU/g as compared to GC-C^+/+ livers. (*P ≤ 0.003). B: Gross areas of necrosis were apparent in the livers of some GC-C^−/− mice at necropsy while none were seen in GC-C^+/+ livers. C: Representative photomicrographs illustrate the presence of lymphocyte aggregates (black arrows) and areas of hemorrhage visible only in GC-C^−/− mice (original magnification 200x).