TY - JOUR AU - Mann, Elizabeth A. AU - Harmel-Laws, Eleana AU - Cohen, Mitchell B. AU - Steinbrecher, Kris A. PY - 2013 DA - 2013/09/02 TI - Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen JO - BMC Gastroenterology SP - 135 VL - 13 IS - 1 AB - Guanylate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is expressed on epithelial cells of the intestine. Activation of GC-C by the endogenous ligands guanylin or uroguanylin elevates intracellular cGMP and is implicated in intestinal ion secretion, cell proliferation, apoptosis, intestinal barrier function, as well as the susceptibility of the intestine to inflammation. Our aim was to determine if GC-C is required for host defense during infection by the murine enteric pathogen Citrobacter rodentium of the family Enterobacteriacea. SN - 1471-230X UR - https://doi.org/10.1186/1471-230X-13-135 DO - 10.1186/1471-230X-13-135 ID - Mann2013 ER -