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Table 7 Effects of NAC on EGFR, AR, TNF-α and TLR4 mRNA levels in the colonic mucosa

From: Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model

Items Control AA NAC
EGFR 1.00 ± 0.29b 0.82 ± 0.19ab 0.61 ± 0.12a
AR 1.00 ± 0.17a 1.28 ± 0.20a 1.58 ± 0.17b
TNF-α 1.00 ± 0.16b 0.61 ± 0.16a 0.60 ± 0.11a
TLR4 1.00 ± 0.04 0.86 ± 0.34 0.71 ± 0.10
  1. Data are means ± SD, n = 6. Control = piglets fed the basal diet and received intrarectal administration of sterile saline; AA = piglets fed the basal diet and received intrarectal administration of acetic acid; NAC = piglets fed the basal diet supplemented with 500 mg/kg NAC and received intrarectal administration of acetic acid. a-b: Values within a row with different letters differ (P < 0.05). EGFR = epidermal growth factor receptor; AR = amphiregulin; TNF-α = tumor necrosis factor-alpha; TLR4 = toll-like receptor 4.