Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model

BMC Gastroenterology

Table 7 Effects of NAC on EGFR, AR, TNF-α and TLR4 mRNA levels in the colonic mucosa

Items	Control	AA	NAC
EGFR	1.00 ± 0.29^b	0.82 ± 0.19^ab	0.61 ± 0.12^a
AR	1.00 ± 0.17^a	1.28 ± 0.20^a	1.58 ± 0.17^b
TNF-α	1.00 ± 0.16^b	0.61 ± 0.16^a	0.60 ± 0.11^a
TLR4	1.00 ± 0.04	0.86 ± 0.34	0.71 ± 0.10

Data are means ± SD, n = 6. Control = piglets fed the basal diet and received intrarectal administration of sterile saline; AA = piglets fed the basal diet and received intrarectal administration of acetic acid; NAC = piglets fed the basal diet supplemented with 500 mg/kg NAC and received intrarectal administration of acetic acid. ^a-b: Values within a row with different letters differ (P < 0.05). EGFR = epidermal growth factor receptor; AR = amphiregulin; TNF-α = tumor necrosis factor-alpha; TLR4 = toll-like receptor 4.

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