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Table 6 Effects of NAC on proinflammatory mediators and growth modulator in the plasma and colonic mucosa

From: Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model

Item Control AA NAC
Plasma    
TNF-α, ng/mL 0.61 ± 0.17a 0.84 ± 0.11b 0.49 ± 0.14a
IL-6, pg/mL 106.4 ± 23.6 115.2 ± 34.2 113.6 ± 18.3
PGE2, pg/mL 57.9 ± 11.5 55.1 ± 13.1 51.9 ± 11.8
EGF, ng/mL 0.65 ± 0.08ab 0.60 ± 0.07a 0.76 ± 0.10b
Colonic mucosa    
IL-6, pg/mL 134.3 ± 12.7 133.6 ± 17.2 130.8 ± 11.3
PGE2, pg/mL 74.5 ± 3.9a 96.0 ± 14.5b 90.5 ± 15.0b
TGF-α, pg/mL 3.50 ± 0.83a 4.28 ± 0.33b 2.56 ± 0.54c
  1. Data are means ± SD, n = 6. Control = piglets fed the basal diet and received intrarectal administration of sterile saline; AA = piglets fed the basal diet and received intrarectal administration of acetic acid; NAC = piglets fed the basal diet supplemented with 500 mg/kg NAC and received intrarectal administration of acetic acid. a, b, c Values within a row with different letters differ (P < 0.05). TNF-α tumor necrosis factor-alpha, IL-6 interleukin 6, PGE 2 prostaglandin E2, EGF epidermal growth factor, TGF-α transforming growth factor-α.