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Table 5 Effects of NAC on redox status in the plasma and colonic mucosa of AA-induced piglets

From: Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model

Items

Control

AA

NAC

Plasma

   

MPO, U/ L

136 ± 12a

172 ± 24b

150 ± 24a

SOD, U/ mL

87.3 ± 30.2

82.0 ± 13.6

77.2 ± 11.8

CAT, U/ mL

4.58 ± 1.29

3.64 ± 1.03

6.50 ± 3.19

MDA, nmol/ mg protein

5.12 ± 0.51a

6.97 ± 1.24b

5.41 ± 1.02a

Colonic mucosa

   

MPO, U/g wet mucosa

0.071 ± 0.003a

0.095 ± 0.018b

0.063 ± 0.016a

SOD, U/mg protein

20.9 ± 1.4

18.5 ± 4.2

20.5 ± 6.0

CAT, U/mg protein

1.16 ± 0.12b

0.99 ± 0.17a

0.87 ± 0.16a

MDA, nmol/mg protein

0.33 ± 0.04a

0.58 ± 0.16b

0.41 ± 0.15a

  1. Data are means ± SD, n = 6. Control = piglets fed the basal diet and received intrarectal administration of sterile saline; AA = piglets fed the basal diet and received intrarectal administration of acetic acid; NAC = piglets fed the basal diet supplemented with 500 mg/kg NAC and received intrarectal administration of acetic acid. a-b: Values within a row with different letters differ (P < 0.05).
  2. MPO Myeloperoxidase, SOD superoxide dismutase, CAT catalase, MDA malondialdehyde.