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Table 5 Effects of NAC on redox status in the plasma and colonic mucosa of AA-induced piglets

From: Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model

Items Control AA NAC
Plasma    
MPO, U/ L 136 ± 12a 172 ± 24b 150 ± 24a
SOD, U/ mL 87.3 ± 30.2 82.0 ± 13.6 77.2 ± 11.8
CAT, U/ mL 4.58 ± 1.29 3.64 ± 1.03 6.50 ± 3.19
MDA, nmol/ mg protein 5.12 ± 0.51a 6.97 ± 1.24b 5.41 ± 1.02a
Colonic mucosa    
MPO, U/g wet mucosa 0.071 ± 0.003a 0.095 ± 0.018b 0.063 ± 0.016a
SOD, U/mg protein 20.9 ± 1.4 18.5 ± 4.2 20.5 ± 6.0
CAT, U/mg protein 1.16 ± 0.12b 0.99 ± 0.17a 0.87 ± 0.16a
MDA, nmol/mg protein 0.33 ± 0.04a 0.58 ± 0.16b 0.41 ± 0.15a
  1. Data are means ± SD, n = 6. Control = piglets fed the basal diet and received intrarectal administration of sterile saline; AA = piglets fed the basal diet and received intrarectal administration of acetic acid; NAC = piglets fed the basal diet supplemented with 500 mg/kg NAC and received intrarectal administration of acetic acid. a-b: Values within a row with different letters differ (P < 0.05).
  2. MPO Myeloperoxidase, SOD superoxide dismutase, CAT catalase, MDA malondialdehyde.