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Table 3 Effects of NAC supplementation on the colonic mucosal morphology of AA-treated piglets

From: Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model

Items Control AA NAC
Score 6.3 ± 1.5a 12.5 ± 2.6b 8.3 ± 1.8a
Crypt Depth1, μm 190 ± 2.2 200 ± 3.5 231 ±3.8
Goblet cells/100 enterocytes 10.3 ± 2.2b 7.4 ±0.7a 9.8 ±1.6b
IEL2/100 enterocytes 1.6 ± 0.5a 2.7 ± 0.8b 1.8 ± 0.9a
Cell density3 1.3 ± 0.4 0.9 ± 0.3 1.0 ± 0.1
Lymphocytic density3 1.6 ± 0.2a 2.4 ± 0.7b 1.7 ± 0.3a
  1. Data are means ± SD, n = 6. Control = piglets fed the basal diet and received intrarectal administration of sterile saline; AA = piglets fed the basal diet and received intrarectal administration of acetic acid; NAC = piglets fed the basal diet supplemented with 500 mg/kg NAC and received intrarectal administration of acetic acid. a-b: Values within a row with different letters differ (P < 0.05). 1Crypt depth: The distance from the crypt mouth to the base. The same crypt columns were used to determine the number of IEL, goblet cells expressed per 100 enterocytes. 2IEL = Intraepithelial lymphocytes. 3 Intravillus lamina propria cell and lymphocytic density expressed as number of total cells or number of lymphocytes per 1,000 μm2.