Table 7 Risk of rs2607474 GG homozygote in H. pylori positive or negative subjects

H. pylori negative (189)

GG

GA

AA

GG vs GA + AA; OR (95%CI)

p value

unmethylated (109)

73

35

1

reference

-

methylated (80)

67

12

1

2.70 (1.31-5.57)

0.0074

H. pylori positive (338)

unmethylated (122)

82

37

3

reference

-

methylated (216)

179

35

2

2.29 (1.36-3.86)

0.0018

CDH1 gene methylation

H. pylori negative (189)

GG

GA

AA

GG vs A carrier; OR (95%C.I.)

p value

unmethylated (129)

86

41

2

reference

-

methylated (60)

54

6

0

4.43 (1.76-11.1)

0.0016

H. pylori positive (338)

unmethylated (152)

111

37

4

reference

-

methylated (186)

150

35

1

1.50 (0.900-2.51)

0.12