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Table 6 Risk of rs2697474 GG homozygote in younger or older subjects

From: Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1in the gastric epithelium

DAPK methylation

     

= < 60 (233)

GG

GA

AA

GG vs GA + AA; OR (95%CI)

p value

unmethylated (115)

80

32

3

reference

-

methylated (118)

96

21

1

2.12 (1.13-3.98)

0.020

60 < (294)

     

unmethylated (116)

75

40

1

reference

-

methylated (178)

150

26

2

2.72 (1.55-4.80)

0.0005

CDH1 methylation

     

= < 60 (233)

GG

GA

AA

GG vs A carrier; OR (95%C.I.)

p value

unmethylated (121)

88

29

4

reference

-

methylated (112)

88

24

0

1.55 (0.827-2.91)

0.17

60 < (294)

     

unmethylated (160)

109

49

2

reference

-

methylated (134)

116

17

1

2.81 (1.53-5.17)

0.0009

  1. by logistic regression analysis after adjustment for age, gender and H. pylori infection status.
  2. (): the number of subjects.