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Table 5 Risk of −1018 GG homozygote for the development of CDH1 methylation

From: Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1in the gastric epithelium

Overall (527) GG GA AA GG vs A carrier; OR (95%C.I.) p value
unmethylated (281) 197 78 6 reference -
methylated (246) 204 41 1 2.07 (1.35-3.17) 0.0009
non-GC (412)      
unmethylated (262) 180 76 6 reference -
methylated (150) 125 24 1 2.25 (1.35-3.75) 0.0019
GC (115)      
(non cancerous mucosa)      
unmethylated (19) 17 2 0 reference -
methylated (96) 79 17 0 0.579 (0.120-2.80) 0.50
(cancer lesion)      
unmethylated (37) 30 7 0 reference -
methylated (78) 66 12 0 1.50 (0.507-4.42) 0.47
  1. by logistic regression analysis after adjustment for age, gender and H. pylori infection status.
  2. (): the number of subject.