Skip to main content

Table 4 Risk of −1018 GG homozygote for the development of DAPK methylation

From: Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1in the gastric epithelium

Overall (527)

GG

GA

AA

GG vs A carrier; OR (95%C.I.)

p value

unmethylated (231)

155

72

4

reference

-

methylated (296)

246

47

3

2.43 (1.60-3.69)

<0.0001

non-GC (412)

     

unmethylated (211)

138

69

4

reference

-

methylated (201)

167

31

3

2.61 (1.62-4.20)

<0.0001

GC (115)

     

(non cancerous mucosa)

     

unmethylated (20)

17

3

0

reference

-

methylated (95)

79

16

0

0.825 (0.379-3.73)

0.78

(cancer lesion)

     

unmethylated (11)

10

1

0

reference

-

methylated (104)

86

18

0

0.598 (0.069-5.19)

0.64

  1. by logistic regression analysis after adjustment for age, gender and H. pylori infection status.
  2. (): the number of subjects.