Figure 1

Deletion of Foxp3 ⁺ Treg leads to weight loss and death. (A) Body weight as a percent of starting weight of PBS-treated and DTx-treated Foxp3-GFP-DTR mice. DTx was administered every other day until the end of the observation period. Every group initially contained 10 mice. Data shown are representative for 3 independent experiments. Error bars represent the SEM. (B) Kaplan Meier Survival curve of PBS-treated and DTx-treated Foxp3-GFP-DTR mice. DTx was administered every other day until the end of the observation period. Every group initially contained 10 mice. Data shown are representative for 3 independent experiments. Log rank test revealed statistical significance with p=0.0021.