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Table 3 Positivity rates and test characteristics of single FIT sampling for advanced neoplasia‡ in three different indication groups in 1041 asymptomatic, high-risk subjects referred for surveillance colonoscopy

From: Faecal immunochemical test accuracy in patients referred for surveillance colonoscopy: a multi-centre cohort study

   Indication groups
   Personal history of adenomas (n = 516) Personal history of CRC§ (n = 172) Family history of CRC§ (n = 353) Total (n = 1041)
Test characteristics Positivity rate 14% 12% 7% 11%
  N 70/516 21/172 24/353 115/1041
  Sensitivity 32% 36% 21% 30%
  N 19/60 8/22 5/24 32/106
  (CI in %) (20–45) (17–59) (7–42) (22–40)
  Specificity 89% 91% 94% 91%
  N 405/456 137/150 310/329 852/935
  (CI in %) (86–92) (86–95) (91–96) (89–93)
  PPV * 27% 38% 21% 28%
  N 19/70 8/21 5/24 32/115
  (CI in %) (17–39) (18–62) (7–42) (20–37)
  NPV 91% 91% 94% 92%
  N 405/446 137/151 310/329 852/926
  (CI in %) (88–93) (85–95) (91–96) (90–94)
  1. Advanced neoplasia is defined as either one or more advanced adenoma(s) or a CRC.
  2. * PPV: positive predictive value.
  3. † NPV: negative predictive value.
  4. § CRC: colorectal cancer.