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Table 2 Test characteristics of single and double FIT sampling (OC-sensor) for colorectal cancer and advanced adenoma at a cut-off level of 50 ng/ml in asymptomatic, high-risk subjects referred for surveillance colonoscopy

From: Faecal immunochemical test accuracy in patients referred for surveillance colonoscopy: a multi-centre cohort study

  Single FIT (n = 1041) Double FIT (one FIT+) (n = 451)   
  CRC§ (n = 5) Advanced adenoma‡ ( n = 101) CRC§ (n = 2) Advanced adenoma‡ (n = 40)
Sensitivity 80% 28% 50% 33%
N 4/5 28/101 1/2 13/40
(CI in %) (28–99) (19–38) (1–99) (19–49)
Specificity 89% 91% 81% 82%
N 925/1036 852/935 363/449 336/409
(CI in %) (87–91) (89–93) (77–84) (78–86)
PPV * 3% 24% 1% 15%
N 4/115 28/115 1/87 13/87
(CI in %) (1–9) (17–33) (0,03–6) (8–24)
NPV 99,9% 92% 99,7% 93%
N 925/926 853/926 363/364 337/364
(CI in %) (99–100) (90–94) (98–99,9) (89–95)
  1. * PPV: positive predictive value.
  2. † NPV: negative predictive value.
  3. § CRC: colorectal cancer.
  4. ‡ Advanced adenoma: Adenomas ≥1.0 cm, with any villous features (i.e. tubulovillous or villous adenoma) or high-grade dysplasia.