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Table 1 Clinicopathological characteristics, MYC , hTERT and TP53 expression , and TP53 copies in gastric samples

From: hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions

  Superficial gastritis Atrophic gastritis Intestinal metaplasia
Gender
Male [N (%)] 12 (63.2) 11 (61.1) 12 (66.7)
Female [N (%)] 7(36.8) 7 (38.9) 6 (33.3)
Alcohol consumption
Negative [N (%)] 10 (52.6) 10 (55.6) 12 (66.7)
Positive [N (%)] 9 (47.4) 8 (44.4) 6 (33.3)
Cigarette smoking
Negative [N (%)] 10 (52.6) 12 (66.7) 9 (50)
Positive* [N (%)] 9 (47.4) 6 (33.3) 9 (50)
H. pylori infection
Negative [N (%)] 7 (36.8) 5 (27.8) 1 (5.6)
Positive [N (%)] 12 (63.2) 13 (72.2) 17 (94.4)
hTERT mRNA expression
RQ (Mean ± SD) 1.092 ± 0.61 0.821 ± 0.47 1.184 ± 0.55
MYC mRNA expression
RQ (Mean ± SD) 0.852 ± 0.51** 0.873 ± 0.28** 1.901 ± 0.49
TP53 mRNA expression
RQ (Mean ± SD) 0.997 ± 0.59 0.847 ± 0.79 1.021 ± 0.61
hTERT immunoreactivity
Negative [N (%)] 19 (100) 18 (100) 10 (55.6)
Positive [N (%)] 0 (0)** 0 (0)** 8 (44.4)
MYC immunoreactivity
Negative [N (%)] 19 (100) 18 (100) 10 (55.6)
Positive [N (%)] 0 (0)** 0 (0)** 8 (44.4)
p53immunoreactivity
Negative [N (%)] 19 (100) 18 (100) 12 (66.7)
Positive [N (%)] 0 (0)** 0 (0)** 6 (33.3)
TP53 copies
2 copies [N (%)] 18 (100) 18 (100) 15 (83.3)
1 copy [N (%)] 0 (0) 0 (0) 3 (16.7)***
  1. RQ: relative quantification.
  2. *Patients smoking one or more cigarettes per day (range 1–20).
  3. **Significantly different from intestinal metaplasia group.
  4. ***Gastritis was significantly different from intestinal metaplasia group.