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Figure 2 | BMC Gastroenterology

Figure 2

From: Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia

Figure 2

Mean short circuit signals. A: Induced SCC by 500 mM of the 4 cNTs presented as mean ± SEM. Control patients: cAMP (N = 7, n = 10), cGMP (N = 5, n = 7), db-cAMP (N = 7, n = 14), db-cGMP (N = 7, n = 12). Neoplasia patients: cAMP (N = 7, n = 12), cGMP (N = 10, n = 20), db-cAMP (N = 10, n = 32), db-cGMP (N = 4, n = 7). B: Responses to application of theophylline and indomethacin. Bars represent Mean ± SEM. Control patients: Theophylline (N = 8, n = 25), indomethacine (N = 8, n = 27). Neoplasia patients: Theophylline (N = 11, n = 37), indomethacine (N = 11, n = 41). C: Responses to application of bumetanide and acetazolamide. Bars represent Mean ± SEM. Control patients: Bumetanide (N = 6, n = 12), acetazolamide (N = 5, n = 11). Neoplasia patients: Bumetanide (N = 9, n = 24), acetazolamide (N = 9, n = 25). N = number of patients and n = number of biopsies. * indicates a statistical significant difference between the two groups.

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BMC Gastroenterology

ISSN: 1471-230X

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