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Table 2 List of additional significant proteins identified in UC patients

From: Comparative analysis of inflamed and non-inflamed colon biopsies reveals strong proteomic inflammation profile in patients with ulcerative colitis

Spot

Protein Name

SwissProt Acc.no.

S cov %1

pI2

Mw2

Fold diff.3

 T -test (p)4

Higher level in RE

15

Superoxide dismutase

P04179

61a

7.0

22

1.9

1.076e-007

16

Peroxiredoxin-4

Q13162

59a

5.8

31

1.7

1.510e-006

17

F-actin capping protein subunit alpha-1

P52907

44a

5.5

33

1.6

8.491e-005

18

Inorganic Pyrophosphatase

Q15181

48a

5.5

33

1.4

1.461e-004

19

Triosephosphate isomerase

P60174

48a

7.7

27

2.0

3.173e-004

20

Actin cytoplasmic

P60709

62a

5.2

42

1.8

5.368e-004

21

Thiosulfate sulfurtransferase

Q16762

49a

6.9

34

1.3

0.004

22

Serum albumin

P02768

16a

5.9

71

1.4

0.005

23

Serum albumin

P02768

5a

5.9

71

1.8

0.005

24

Proteasome activator

Q9UL46

53a

5.4

28

1.2

0.005

25

Serotransferrin

P02787

24a

7.0

79

1.4

0.014

26

F-actin capping protein subunit beta

P47756

45a

5.6

31

1.1

0.025

Lower level in RE

27

Selenium binding protein

Q13228

60a

5.9

53

1.4

1.525e-006

28

Protein ETHE1

O95571

56a

6.4

28

1.4

2.911e-006

29

Enoyl-CoA hydratase

P30084

46a

9.4

32

1.3

7.862e-006

30

Isocitrate dehydrogenase

O75874

35a

6.6

47

1.7

9.730e-006

31

Elongation factor Tu

P49411

52a

7.9

50

1.4

2.055e-005

32

Peroxiredoxin-6

P30041

63a

6.0

25

1.4

8.820e-005

33

Tubulin alpha-6 chain

Q9BQE3

29a

4.8

50

 

4.100e-005

34

Carbonic anhydrase 1

P00915

46a

6.7

29

2.0

1.354e-004

35

Annexin A1

P04083

34

6.7

39

1.3

2.942e-004

36

Cathepsin D

P07339

33a

6.1

45

1.3

3.062e-004

37

Thioredoxin-dependent peroxide reductase

P30048

55a

8.9

28

1.3

0.001

38

Heat shock protein 70 kDa /Serum albumin

P08107/P02768

33a/66a

5.9/5.4

70/71

1.4

0.004

39

60 kDa heat shock protein

P10809

41a

5.6

61

1.3

0.014

40

Serum albumin

P02768

18a

5.9

71

1.3

0.019

41

Triosephosphate isomerase

P60174

63a

6.5

27

1.3

0.019

42

Serum albumin

P02768

20a

5.9

71

1.3

0.021

43

Alpha-enolase

P06733

42a

7.7

47

1.1

0.042

  1. 1Percentage sequence coverage (S cov %) is followed by a if the mascot score was significant (P < 0.05). 2Theoretical isoelectric point (pI) and theoretical molecular weight (Mw) are presented. 3Fold difference in protein level. 4p-value from t-test. 5The protein was identified by MS/MS.
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BMC Gastroenterology

ISSN: 1471-230X

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