Univariate analysis | |||
---|---|---|---|
Factors | Platelets < 50 × 103/μL | Platelets ≥ 50 × 103/μL | Pvalue |
Age, years | 58 ± 11 | 57 ± 10 | 0.663 |
Male/female | 9/7 | 56/53 | 0.463 |
BMI, kg/m2 | 23.37 ± 2.65 | 25.30 ± 3.19 | 0.022 |
ALB, g/dL | 3.96 ± 0.30 | 4.16 ± 0.30 | 0.020 |
Total bilirubin, mg/dL | 0.9 ± 0.4 | 0.8 ± 0.3 | 0.179 |
AST, U/L | 147.44 ± 80.26 | 116.78 ± 62.33 | 0.145 |
ALT, U/L | 200 ± 130 | 196 ± 116 | 0.909 |
ALK-p, U/L | 113.20 ± 32.52 | 96.56 ± 31.62 | 0.065 |
Prothrombin time (INR) | 1.07 ± 0.07 | 1.05 ± 0.05 | 0.111 |
WBC count,/cumm | 4954 ± 1169 | 5303 ± 1215 | 0.338 |
Hgb, g/dL | 13.86 ± 0.86 | 14.47 ± 1.49 | 0.101 |
Platelets, × 103/μL | 100.63 ± 23.21 | 124.83 ± 18.74 | < 0.001 |
Necroinflammatory activity, A0+A1/A2+A3 | 6/5 | 56/19 | 0.152 |
Fibrosis status, F1+F2/F3+F4 | 4/8 | 29/50 | 0.547 |
Cirrhosis, yes/no | 5/11 | 23/86 | 0.269 |
Splenomegaly yes/no (%) | 5/11 | 22/86 | 0.247 |
HCV-RNA, log10 IU/mL | 5.41 ± 1.42 | 6.09 ± 0.96 | 0.033 |
HCV genotype- 1/2 | 5/11 | 66/43 | 0.033 |
Peg-IFN-α-2a/-α-2b | 6/10 | 42/67 | 0.583 |
Peg-IFN-α-2a dose, μg/week | 180 ± 0 (n = 6) | 179 ± 9 (n = 42) | 0.705 |
Peg-IFN-α-2b dose, μg/week | 89 ± 11 (n = 10) | 93 ± 12 (n = 67) | 0.370 |
Ribavirin dose, mg/day | 811 ± 169 | 900 ± 166 | 0.079 |
Rate of PLT decline at week 2, % | 38.46 ± 11.53 | 14.06 ± 21.85 | < 0.001 |