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Table 1 Characteristics of 125 patients with chronic hepatitis C

From: Factors linked to severe thrombocytopenia during antiviral therapy in patients with chronic hepatitis c and pretreatment low platelet counts

Variables Median (25th-75thpercentile values) or number (percentage)
Age (years) 57 (25-64)
Gender (male/female) 65/60 (52/48)
BMI (kg/m2) 24.8 (23.0-27.0)
Albumin (g/dL) 4.1 (3.9-4.4)
Total bilirubin (mg/dL) 0.7 (0.6-1.0)
AST (U/L) 107 (72-159)
ALT (U/L) 160 (109-259)
ALK-p (U/L) 96 (72-121)
PT INR 1.04 (1.01-1.08)
WBC (/mm3) 5,120 (4,403-6,083)
Hgb (g/dL) 14.4 (13.3-15.5)
Platelets (/μL) 125,000 (110,000-140,500)
Fibrosis (F1/2/3/4) 2/31/39/19 (1.6/24.8/31.2/15.2)#
Necroinflammatory activity (A0/1/2/3) 13/49/21/3 (10.4/38.2/16.8/2.4)#
Cirrhosis status (yes/no) 28/97 (22.4/77.6)
HCV-RNA (log10, IU/mL) 6.12 (5.39-6.66)
HCV genotype (1/2) 71/54 (56.8/43.2)
Splenomegaly (yes/no) 27/97 (21.6/77.6)§
Peg-IFN-α-2a/-α-2b 48/77 (38.4/61.6)
Dose of ribavirin (mg/day) 867 (800-1000)
  1. Abbreivations: ALK-p: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; Hgb: hemoglobin; HCV: hepatitic C virus; PT INR: international normalized ratio of prothrombin time; WBC: white blood cells; Peg-IFN: pegylated-interferon.
  2. #Only the patients undergoing liver biopsy were analyzed for fibrosis and necroinflammatory activity of liver tissue. F1-F4 represent fibrotic scores, and A0-A3 mean necroinflammatory scores, according to METAVIR scoring system [10].
  3. §One patient had undergone splenectomy due to traumatic splenic rupture.