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Table 1 Demographic and clinical-pathologic comparisons of patients with HCC associated with underlying HBV vs. those with HCV-associated HCC

From: Hepatitis B vs. hepatitis C infection on viral hepatitis-associated hepatocellular carcinoma

   All (n = 127) HBV (n = 89) HCV (n = 38) P value †
Gender
  Male 115 (90%) 85 (95%) 30 (79%) p = 0.007
  Female 12 (10%) 4 (5%) 8 (21%)  
Race
  Asian 82 (65%) 80 (90%) 2 (5%) p < 0.001
  Non-Asian 45 (35%) 9 (10%) 36 (95%)  
Age
  Median 53 50 58 NS
  Range 21-79 21-75 47-79  
  Distribution     
  21-30 5 (4%) 5 (6%) 0 (0%)  
  31-40 18 (14%) 18 (20%) 0 (0%) p < 0.001 ‡
  41-50 23 (18%) 21 (24%) 2 (5%)  
  51-60 50 (39%) 28 (31%) 22 (58%)  
  >60 31 (24%) 17 (19%) 14 (37%)  
Comorbidities
  Mean ± S.D 1.6 ± 1.6 1.0 ± 1.1 2.9 ± 1.5 p < 0.001
Alcohol abuse
   18 (15%) 6 (7%) 12 (32%) p < 0.001
HIV coinfection
   8 (6%) 1 (1%) 7 (13%) p < 0.001
Cirrhosis state in the non-neoplastic liver (n = 119)
  Non-cirrhosis 34 (29%) 34 (40%) 0 (0%) p < 0.001
  Cirrhosis 85 (71%) 50 (60%) 35 (100%)  
AFP levels (n = 122)
  Median 137 1000 37 p = 0.002
  Range 3-871,485 3-871,485 4-59,739  
  Distribution     
  ≤ 9 20 (16%) 13 (15%) 7 (19%) NS *
  9-20 10 (8%) 7 (8%) 3 (8%) NS *
  20-100 27 (22%) 10 (12%) 17 (46%) p < 0.001 *
  100-1,000 15 (12%) 11 (13%) 4 (11%) p < 0.001 *
  1,000-10,000 27 (22%) 23 (27%) 4 (11%) p = 0.01 *
  >10,000 23 (19%) 21 (25%) 2 (5%)  
  1. † P values were obtained by Fisher’s exact test, two-tailed t test or non-parametric Mann–Whitney U test.
  2. ‡ p < 0.001 when comparing HCC developing under age 40 in HBV vs. HCV.
  3. * p values obtained when comparing distribution with AFP cut-off at 9, 20, 100, 1,000, or 10,000 in HBV vs. HCV.
  4. NS: not significant.