Table 1 Demographic and clinical-pathologic comparisons of patients with HCC associated with underlying HBV vs. those with HCV-associated HCC
From: Hepatitis B vs. hepatitis C infection on viral hepatitis-associated hepatocellular carcinoma
|  |  | All (n = 127) | HBV (n = 89) | HCV (n = 38) | P value †|
|---|---|---|---|---|---|
Gender | |||||
|  | Male | 115 (90%) | 85 (95%) | 30 (79%) | p = 0.007 |
| Â | Female | 12 (10%) | 4 (5%) | 8 (21%) | Â |
Race | |||||
|  | Asian | 82 (65%) | 80 (90%) | 2 (5%) | p < 0.001 |
| Â | Non-Asian | 45 (35%) | 9 (10%) | 36 (95%) | Â |
Age | |||||
| Â | Median | 53 | 50 | 58 | NS |
| Â | Range | 21-79 | 21-75 | 47-79 | Â |
| Â | Distribution | Â | Â | Â | Â |
| Â | 21-30 | 5 (4%) | 5 (6%) | 0 (0%) | Â |
|  | 31-40 | 18 (14%) | 18 (20%) | 0 (0%) | p < 0.001 ‡ |
| Â | 41-50 | 23 (18%) | 21 (24%) | 2 (5%) | Â |
| Â | 51-60 | 50 (39%) | 28 (31%) | 22 (58%) | Â |
| Â | >60 | 31 (24%) | 17 (19%) | 14 (37%) | Â |
Comorbidities | |||||
|  | Mean ± S.D | 1.6 ± 1.6 | 1.0 ± 1.1 | 2.9 ± 1.5 | p < 0.001 |
Alcohol abuse | |||||
|  |  | 18 (15%) | 6 (7%) | 12 (32%) | p < 0.001 |
HIV coinfection | |||||
|  |  | 8 (6%) | 1 (1%) | 7 (13%) | p < 0.001 |
Cirrhosis state in the non-neoplastic liver (n = 119) | |||||
|  | Non-cirrhosis | 34 (29%) | 34 (40%) | 0 (0%) | p < 0.001 |
| Â | Cirrhosis | 85 (71%) | 50 (60%) | 35 (100%) | Â |
AFP levels (n = 122) | |||||
|  | Median | 137 | 1000 | 37 | p = 0.002 |
| Â | Range | 3-871,485 | 3-871,485 | 4-59,739 | Â |
| Â | Distribution | Â | Â | Â | Â |
|  | ≤ 9 | 20 (16%) | 13 (15%) | 7 (19%) | NS * |
| Â | 9-20 | 10 (8%) | 7 (8%) | 3 (8%) | NS * |
|  | 20-100 | 27 (22%) | 10 (12%) | 17 (46%) | p < 0.001 * |
|  | 100-1,000 | 15 (12%) | 11 (13%) | 4 (11%) | p < 0.001 * |
|  | 1,000-10,000 | 27 (22%) | 23 (27%) | 4 (11%) | p = 0.01 * |
| Â | >10,000 | 23 (19%) | 21 (25%) | 2 (5%) | Â |