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Table 1 Cohort baseline at menopause diagnosis according to use or non-use of hormone

From: Hormone replacement therapy is associated with gastro-oesophageal reflux disease: a retrospective cohort study

Characteristics

Oestrogen Users N = 7678)

Tibolone Users N = 1539

Combined Hormone users N = 9137

Progestogen Users N = 3747

Non-users N = 29081 (%)

Age (y)

40 to 49

2987 (39%)

275 (18%)

3941 (43%)

2212 (59%)

9795 (34%)

 

50 to 59

3229 (42%)

902 (59%)

4464 (49%)

1348 (36%)

13189 (45%)

 

60 to 70

1462 (19%)

362 (24%)

732 (8%)

187 (5%)

6097 (21%)

 

Mean (SD)

52.6 (7.23)

55.1 (6.16)

50.9 (5.54)

49.1 (5.44)

53.4 (7.24)

Alcohol user 1

Non-user

583 (16%)

104 (14%)

617 (14%)

279 (16%)

2243 (17%)

 

User

3097 (83%)

615 (85%)

3840 (85%)

1437 (83%)

10386 (81%)

 

Ex-user

69 (2%)

7 (1%)

57 (1%)

20 (1%)

197 (2%)

Smoker 2

Non-user

2526 (53%)

501 (54%)

2966 (52%)

1208 (54%)

9719 (59%)

 

User

1452 (30%)

279 (30%)

1817 (32%)

720 (32%)

4010 (24%)

 

Ex-user

800 (17%)

149 (16%)

955 (17%)

317 (14%)

2766 (17%)

BMI 3

Underweight

76 (2%)

13 (1%)

86 (2%)

24 (1%)

222 (1%)

 

Normal

1928 (41%)

374 (40%)

2524 (44%)

833 (39%)

5771 (37%)

 

Overweight

1606 (34%)

338 (36%)

1943 (34%)

627 (30%)

5038 (32%)

 

Obese

1004 (21%)

194 (21%)

1034 (18%)

530 (25%)

3812 (25%)

 

Morbidly Obese

121 (3%)

25 (3%)

122 (2%)

104 (5%)

702 (5%)

 

Mean (SD)

26.9 (5.47)

27.1 (5.80)

26.4 (5.17)

27.7 (6.39)

27.7 (6.11)

Practice IMD 4

0

1759 (23%)

311 (20%)

1988 (22%)

832 (22%)

6112 (21%)

 

1

1252 (16%)

248 (16%)

1609 (18%)

702 (19%)

5287 (16%)

 

2

1578 (21%)

255 (17%)

1804 (20%)

764 (20%)

5743 (20%)

 

3

1453 (19%)

344 (22%)

1751 (19%)

731 (20%)

5757 (20%)

 

4

1636 (21%)

381 (25%)

1985 (22%)

718 (19%)

6182 (21%)

Hysterectomy

3470 (45%)

165 (11%)

462 (5%)

472 (13%)

3229 (11%)

NSAID use

4191 (55%)

879 (57%)

4750 (52%)

2242 (60%)

13993 (48%)

Bisphophonates

188 (2%)

57 (4%)

192 (2%)

53 (2%)

827 (3%)

Calcium supplements

419 (5%)

118 (8%)

477 (5%)

113 (3%)

1707 (6%)

GORD symptoms 5

1915 (25%)

387 (25%)

2031 (22%)

859 (23%)

6689 (23%)

PPI use 5

564 (7%)

88 (6%)

555 (6%)

239 (6%)

1947 (7%)

  1. 154% of patients had missing data.
  2. 241% of patients had missing data.
  3. 343% of patients had missing data.
  4. 4Index of Multiple Deprivation (IMD) based on practice post-code. Quintile 0 is the least deprived, quintile 4 is the most deprived.
  5. 5Prior to menopause.