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Figure 1 | BMC Gastroenterology

Figure 1

From: Dietary L-arginine supplementation reduces Methotrexate-induced intestinal mucosal injury in rat

Figure 1

A. Staining with H@E. Intestinal injury caused by MTX. MTX rats demonstrated a significant epithelial atrophy (thick arrows) and signs of crypt remodeling (thin arrows) which were accompanied by marked cellularity and an increased number of blood vessels (arrowheads) in the stroma. Following ARG administration rats showed less significant epithelial atrophy and crypt remodeling compared to MTX rats. B. BrdU staining (cell proliferation). Control rats show normal crypt compartment. The proliferative zone in MTX-rats moved progressively upwards in the crypts toward the crypt-villus junction. The proliferative zone of MTX-ARG rat was only mildly affected showed the presence of newly formed crypts and signs of regeneration. CONTR-control, MTX-methotrexate, ARG-arginine.

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