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Figure 5 | BMC Gastroenterology

Figure 5

From: Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis

Figure 5

A. Terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) analysis of apoptosis in C57BL6J apoE knock-out and wild-type mice challenged by 5-FU-induced intestinal mucositis (450 mg/kg via i.p., single dose) and treated with the apoE mimetic peptide COG 133 (3 μM, via i.p., 12/12 h, vol. 10 μl/g) or 0.9% saline (i.p.). Values represent mean ± SEM and were analyzed by one-way ANOVA and Bonferroni.. TUNEL-labeled cells (head arrows) were found increased 5-FU treated mice. Effect that was reversed by ApoE COG 133 peptide. Scale bars = 10 μm. B. NF-κB p50 representative immunohistochemistry of the proximal intestine tissue (X400) after four days of 5-FU-challenge. Note higher NF-κB immunlabeling in recovered crypts treated by ApoE COG 133 peptide. Scale bars, 10 μm.

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