Figure 2

Mean mitotic index of the H&E stained-duodenal crypts (X1000) from C57BL6J ApoE knock-out and wild-type mice challenged by 5-FU-induced intestinal mucositis (450 mg/kg via i.p., single dose) and treated with the apoE mimetic peptide COG 133 (3 μM, via i.p., 12/12 h, vol. 10 μl/g) or 0.9% saline (i.p.). Values represent mean ± SEM and were analyzed by one-way ANOVA and Bonferroni. At least 10 crypts per animal were analyzed (n = 4 animals/group).Experimental mice were sacrificed on the fourth day post-challenge.