Figure 1

A. Representative histology and villus height from H-E stained-proximal intestine (X100) of Swiss mice challenged by 5-FU-induced intestinal mucositis (450 mg/kg via i.p., single dose, and treated with the apoE mimetic peptide COG 133 (0.3, 1, and 3 μM, via i.p., 12/12 h, vol. 10 μl/g) or 0.9% saline (i.p.). Scale bar = 100 μm. B. Representative histology and villus height from H-E stained-proximal intestine (X100) of C57BL6J ApoE knock-out and wild-type mice challenged by 5-FU-induced intestinal mucositis (450 mg/kg via i.p., single dose) and treated with the apoE mimetic peptide COG 133 (3 μM, via i.p., 12/12 h, vol. 10 μl/g) or 0.9% saline (i.p.). Scale bar = 100 μm. The arrow indicates a heavy inflammatory cell infiltrate in the submucosal tissue from the 5-FU-treated mice. Note reductions of inflamed tissue in apoE COG 133-treated groups, especially in the highest doses. Values represent mean ± SEM and were analyzed by one-way ANOVA and Bonferroni. At least 10 villi per animal were analyzed (n = 4 animals/group). Experimental mice were sacrificed on the fourth day post-challenge.