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Table 1 Characteristics of study population 1 (n = 144)

From: A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus

Characteristics

 

Total

 

Group1-A

 

Group1-B

 

A vs. B

    

with lichen planus

 

with normal oral mucosa

 

P value

No. subjects

 

144

 

59

 

85

  

Sex

male/female

39/105

 

14/45

 

25/60

 

NS

Age

(mean ± SD), years

67.05 ± 9.87

 

68.05 ± 9.93

 

66.35 ± 9.83

 

NS

Liver disease

positive (%)

73

50.69%

46

77.97%

27

31.76%

< 0.0001

Diagnosis of liver diseases

Past history of HCV infection

13

9.03%

1

1.69%

12

14.12%

 
 

CH-C

31

21.53%

20

33.90%

11

12.94%

 
 

CH-C during IFN

4

2.78%

4

6.78%

0

0.00%

 
 

CH-C post IFN (SVR)

5

3.47%

4

6.78%

1

1.18%

 
 

CH-C + AIH

1

0.69%

1

1.69%

0

0.00%

 
 

CH-C + post HCV-related HCC

3

2.08%

2

3.39%

1

1.18%

 
 

LC-C

3

2.08%

2

3.39%

1

1.18%

 
 

LC-C + post HCV-related HCC

7

4.86%

6

10.17%

1

1.18%

 
 

CH-B

1

0.69%

1

1.69%

0

0.00%

 
 

LC-B

1

0.69%

1

1.69%

0

0.00%

 
 

PBC

1

0.69%

1

1.69%

0

0.00%

 
 

Fatty liver

2

1.39%

2

3.39%

0

0.00%

 
 

Fatty liver + ALD

1

0.69%

1

1.69%

0

0.00%

 
 

Normal liver

71

49.31%

13

22.03%

58

68.24%

 

Diabetes mellitus

positive (%)

14

9.72%

6

10.17%

8

9.41%

NS

Thyroid disease

positive (%)

8

5.56%

6

10.17%

2

2.35%

0.0440

Extrahepatic malignant tumor

positive (%)

15

10.42%

5

8.47%

10

11.76%

NS

Smoking history

yes (%)

37

25.69%

22

37.29%

15

17.65%

0.0080

History of alcohol intake

yes (%)

59

40.97%

19

32.20%

40

47.06%

NS

Anti-HCV

positive (%)

67

46.53%

40

67.80%

27

31.76%

< 0.0001

HCV RNA

positive (%)

49

34.03%

35

59.32%

14

16.47%

< 0.0001

HCV RNA level

High

46

85.19%

32

82.05%

14

93.33%

NS

 

Low

3

5.56%

3

7.69%

0

0.00%

NS

 

unexmained

5

9.26%

4

10.26%

1

6.67%

 

HCV genotype

1b

27

55.10%

27

77.14%

-

  
 

2a

2

4.08%

2

5.71%

-

  
 

2b

0

0.00%

0

0.00%

-

  
 

unexmained

20

40.82%

6

17.14%

14

100.00%

 

HBsAg

positive (%)

3

2.08%

2

3.39%

1

1.18%

NS

BMI

 

22.70 ± 3.20

 

22.44 ± 3.20

 

22.88 ± 3.20

 

NS

AST

(U/L) (mean ± SD)

29.71 ± 16.86

 

36.09 ± 20.33

 

25.65 ± 12.78

 

0.0009

ALT

(U/L) (mean ± SD)

25.47 ± 20.06

 

30.54 ± 22.39

 

22.25 ± 17.82

 

0.0031

LDH

(U/L) (mean ± SD)

202.40 ± 43.56

 

211.42 ± 54.63

 

196.88 ± 34.34

 

NS

ALP

(U/L) (mean ± SD)

272.76 ± 112.57

 

299.62 ± 155.99

 

256.33 ± 70.88

 

NS

TP

(g/dL) (mean ± SD)

7.17 ± 0.42

 

7.27 ± 0.43

 

7.11 ± 0.41

 

NS

Alb

(g/dL) (mean ± SD)

4.15 ± 0.33

 

3.99 ± 0.38

 

4.26 ± 0.25

 

< 0.0001

T.Bil

(mg/dL) (mean ± SD)

1.13 ± 5.27

 

2.03 ± 8.57

 

0.60 ± 0.20

 

< 0.0001

TC

(mg/dL) (mean ± SD)

192.34 ± 35.28

 

179.12 ± 37.18

 

200.12 ± 31.84

 

0.0007

Hb

(g/dL) (mean ± SD)

13.30 ± 1.39

 

13.16 ± 1.39

 

13.39 ± 1.38

 

NS

PLT

(/μL) (mean ± SD)

18.30 ± 5.57

 

15.95 ± 6.42

 

19.71 ± 4.48

 

< 0.0001

  1. HCV, hepatitis C virus; CH-C, chronic hepatitis C; LC-C, liver cirrhosis type C; HCC, hepatocellular carcinoma; CH-B, chronic hepatitis B; LC-B, liver cirrhosis type B; AIH, autoimmune hepatitis; PBC, primary biliary cirrhosis; ALD, alcoholic liver disease; IFN, interferon; NS, not significant; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; ALP, alkaline phosphatase; TP, total protein; Alb, albumin; T.Bil, total bilirubin; TC, total cholesterol; PLT, platelets
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BMC Gastroenterology

ISSN: 1471-230X

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