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Figure 2 | BMC Gastroenterology

Figure 2

From: Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are neuroprotective on cultured and mast cell co-cultured rat myenteric neurons

Figure 2

Survival of myenteric neurons pre-cultured for 4 days followed by 2 days of culture in various concentrations (10 -11 - 10 -6 M) of GLP1, GLP2 or VIP in the absence or presence of GLP1 receptor antagonist (exendin(9-39)amide, 10 -7 M) or VIP receptor antagonist (hybVIP, 10 -9 M). Presence of GLP1, GLP2 and VIP significantly and concentration-dependently increase neuronal survival. Simultaneous addition of exendin(9-39)amide attenuates GLP1-induced neuroprotection while that of GLP2 and VIP are unaffected. Simultaneous addition of hybVIP attenuates GLP1- and VIP-induced neuroprotection while that of GLP2 is unaffected. Means ± SEM, n = 6-21; * p < 0.1; ** p < 0.05; *** p < 0.01 as compared to controls run in parallel without addition of peptides or antagonists.

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BMC Gastroenterology

ISSN: 1471-230X

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