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Table 2 Factors associated with significant fibrosis according to TE (≥ 7.1 kPa), Fibrotest (> 0.48) and TE and Fibrotest combined

From: Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers

  TE F ≥ 2   FT F ≥ 2   TE + FT F ≥ 2  
Variable Multivariate analysis
OR (95% CI)
p-value Multivariate analysis
OR (95% CI)
p-value Multivariate analysis
OR (95% CI)
p-value
HCV-RNA positive 7.29 (1.95-27.34) 0.003     
Chronic AST elevation 6.58 (1.30-33.25) 0.023 2.72 (1.18-6.27) 0.019 137.04 (9.57-1961.89) < 0.0001
Chronic GGT elevation 5.17 (1.56-17.08) 0.007 2.69 (1.30-5.57) 0.008 17.92 (1.52-210.98) 0.022
Total serum cholesterol 0.98 (0.96-0.99) 0.001    0.96 (0.93-0.99) 0.004
Cumulative d-drug exposure (in months) 1.01 (1.00-1.02) 0.035     
Saquinavir    1.02 (1.00-1.03) 0.016 1.03 (1.00-1.06) 0.046
  1. Data of the multivariate analysis are shown
  2. TE, transient elastography; FT, Fibrotest; F ≥ 2, significant liver fibrosis; d-drug exposure, exposure to dideoxynucleosides