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Table 2 Factors associated with significant fibrosis according to TE (≥ 7.1 kPa), Fibrotest (> 0.48) and TE and Fibrotest combined

From: Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers

 

TE F ≥ 2

 

FT F ≥ 2

 

TE + FT F ≥ 2

 

Variable

Multivariate analysis

OR (95% CI)

p-value

Multivariate analysis

OR (95% CI)

p-value

Multivariate analysis

OR (95% CI)

p-value

HCV-RNA positive

7.29 (1.95-27.34)

0.003

    

Chronic AST elevation

6.58 (1.30-33.25)

0.023

2.72 (1.18-6.27)

0.019

137.04 (9.57-1961.89)

< 0.0001

Chronic GGT elevation

5.17 (1.56-17.08)

0.007

2.69 (1.30-5.57)

0.008

17.92 (1.52-210.98)

0.022

Total serum cholesterol

0.98 (0.96-0.99)

0.001

  

0.96 (0.93-0.99)

0.004

Cumulative d-drug exposure (in months)

1.01 (1.00-1.02)

0.035

    

Saquinavir

  

1.02 (1.00-1.03)

0.016

1.03 (1.00-1.06)

0.046

  1. Data of the multivariate analysis are shown
  2. TE, transient elastography; FT, Fibrotest; F ≥ 2, significant liver fibrosis; d-drug exposure, exposure to dideoxynucleosides