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Table 4 Proportion of patients who may potentially avoid liver biopsy using the simple non-invasive tests to exclude advanced fibrosis.

From: Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population

Fibrosis panel Cut-off values Patients avoiding liver biopsya False negative result
FIB4 index < 1.45 336/576 (58%) 6 (2%)
  < 1.30 308/576 (53%) 4 (1%)
AST/ALT ratio (AAR) < 0.8 413/576 (72%) 22 (5%)
AST to platelet ratio index (APRI) < 1 435/576 (76%) 21 (5%)
Age-platelet index (AP index) < 6 421/576 (73%) 22 (5%)
NAFLD fibrosis score < -1.455 328/576 (57%) 5 (2%)
BARD score < 2 355/576 (62%) 13 (4%)
N score < 2 305/576 (53%) 13 (4%)
  1. aPatients with a value below the cut-off.