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Table 1 Formulae for determining noninvasive marker panels for detection of liver fibrosis.

From: Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population

Formula Equation
FIB4 index ( Age [ years ] × AST [IU/L] ) ( platelet count [1 0 9 /L] × ALT[IU/L] )
AST to ALT ratio (AAR) AST/ALT
AST to platelet ratio index (APRI) a ([AST/ULN]/platelet count [109/L]) × 100
Age-platelet index (AP index) Age (years) platelet count (109/L)
  < 30 = 0 < 225 = 0
  30-39 = 1 200-224 = 1
  40-49 = 2 175-199 = 2
  50-59 = 3 150-174 = 3
  60-69 = 4 125-149 = 4
  ≥ 70 = 5 < 125 = 5
  Score is the sum of two (0-10)
NAFLD fibrosis score -1.675 + 0.037 × age (years) + 0.094 ×BMI (kg/m2) + 1.13 × IFG/diabetes (yes = 1, no = 0) + 0.99 × AST/ALT - 0.013 × platelet count (× 109/L) - 0.66 × albumin (g/dL).
BARD score Scale 0-4
  BMI ≥ 28 kg/m2 = 1 point
  AST/ALT ≥ 0.8 = 2 points
  Diabetes = 1 point
N (Nippon) score Scale 0-4
  female sex = 1 point
  older age (> 60 years) = 1 point
  type 2 diabetes = 1 point
  hypertension = 1 point
  1. BMI, body mass index; IFG, impaired fasting glucose; INR, international normalized ratio; ULN, upper limit of normal.aULN for AST: 30 in women, 35 in men.