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Table 3 Frequency of LOH mutations within microdissected targets by histological classifications

From: Correlation of the presence and extent of loss of heterozygosity mutations with histological classifications of Barrett’s esophagus

Loci

Tumor suppressor genes

The number (percent) of microdissected targets with LOH mutations at each loci in each histological classification

Normal squamous

Columnar

Intestinal metaplasia

Indefinite for dysplasia

Low grade dysplasia

High grade dysplasia

N = 82

N = 77

N =216

N = 138

N = 39

N = 16

1p

CMM1, LMYC

1 (1%)

0

13 (6%)

20 (14%)

11 (28%)

5 (31%)

3p

VHL, OGG1

1 (1%)

4 (5%)

29 (13%)

24 (17%)

20 (51%)

8 (50%)

5q

MCC, APC

2 (2%)

8 (10%)

43 (20%)

25 (18%)

11 (28%)

13 (81%)

9p

CDKN2A

4 (5%)

4 (5%)

56 (26%)

45 (33%)

20 (51%)

7 (44%)

10q

PTEN, MXI1

0

11 (14%)

54 (25%)

40 (29%)

12 (31%)

2 (13%)

17p

TP53

1 (1%)

4 (5%)

35 (16%)

49 (36%)

27 (69%)

14 (88%)

17q

NME1

1 (1%)

7 (9%)

21 (10%)

33 (24%)

17 (44%)

9 (56%)

18q

DCC

1 (1%)

7 (9%)

41 (19%)

14 (10%)

12 (31%)

4 (25%)

21q

TFF1, PSEN2

0

3 (4%)

20 (9%)

18 (13%)

7 (18%)

0

22q

NF2

0

0

11 (5%)

3 (2%)

0

2 (13%)

  1. Bold numbers indicate that at least 25% of microdissected targets tested with each histological classification had the indicated LOH mutations.