Loci | Tumor suppressor genes | The number (percent) of microdissected targets with LOH mutations at each loci in each histological classification | |||||
---|---|---|---|---|---|---|---|
Normal squamous | Columnar | Intestinal metaplasia | Indefinite for dysplasia | Low grade dysplasia | High grade dysplasia | ||
N = 82 | N = 77 | N =216 | N = 138 | N = 39 | N = 16 | ||
1p | CMM1, LMYC | 1 (1%) | 0 | 13 (6%) | 20 (14%) | 11 (28%) | 5 (31%) |
3p | VHL, OGG1 | 1 (1%) | 4 (5%) | 29 (13%) | 24 (17%) | 20 (51%) | 8 (50%) |
5q | MCC, APC | 2 (2%) | 8 (10%) | 43 (20%) | 25 (18%) | 11 (28%) | 13 (81%) |
9p | CDKN2A | 4 (5%) | 4 (5%) | 56 (26%) | 45 (33%) | 20 (51%) | 7 (44%) |
10q | PTEN, MXI1 | 0 | 11 (14%) | 54 (25%) | 40 (29%) | 12 (31%) | 2 (13%) |
17p | TP53 | 1 (1%) | 4 (5%) | 35 (16%) | 49 (36%) | 27 (69%) | 14 (88%) |
17q | NME1 | 1 (1%) | 7 (9%) | 21 (10%) | 33 (24%) | 17 (44%) | 9 (56%) |
18q | DCC | 1 (1%) | 7 (9%) | 41 (19%) | 14 (10%) | 12 (31%) | 4 (25%) |
21q | TFF1, PSEN2 | 0 | 3 (4%) | 20 (9%) | 18 (13%) | 7 (18%) | 0 |
22q | NF2 | 0 | 0 | 11 (5%) | 3 (2%) | 0 | 2 (13%) |