Table 1 Comparison of reported patients with SLE complicating Crohn disease
From: Systemic lupus erythematosus complicated by Crohn’s disease: a case report and literature review
Pt | Age/Sex | SLE disease duration | Immunological findings | Sympotom | ESR (mm/hr) | Colonoscopy findings | Result of biopsy | Treatment | Reference |
|---|---|---|---|---|---|---|---|---|---|
1 | 28M | 7years | ANA 1280× Anti-DNA 160× | Diarrhea | 89 | Deep linear and ulceration, pseudopolyps, skip lesion | Acute and clonic inflammation | mPSL40mg/d. d iv | [2] |
pyoderma gangrenosum | |||||||||
2 | 15F | 3years | ANA 1280× Anti-DNA 50× | Abdominal pain | 68 | Multiple ulcers with linear ulcer, skip lesion, Pseudpolyps | Infiltration of chronic inflammatory cells in the lamina proprial mucosa with marked depletion of goblet cells without vasculitis | Salazosulpha-pyridine | [3] |
Diarrhea | |||||||||
Blood stained stool | |||||||||
3 | 55F | 12years | ANA 80× Anti-dsDNA 80×positive LE cell | Intermittent hematochezia, tenesmus and loose bowel movements | 35 | Multiple ulcers with linear ulcer, diffuse aphthous ulcers | active colitis with noncaceating granulomas | Prednisone | [4] |
4 | 25F | She developed SLE four years after developing Crohn’s disease. | ANA 160× Anti-dsDNA 800IU/ml pANCA positive | Watery diarrhea | N/A | Longitudinal ulcers and mucosal erosion | Focal cryptitis with noncaceating granuloma | Salazosulpha-pyridine 3g/d | [5] |
Lower abdominal pain, Perianal abscess | |||||||||
5 | 37M | 9years | ANA 320× Anti-dsDNA320× Anti-DNA 26IU/ml positive LE cell | Diarrhea | 65 | Longitudinal ulcers, linear ulcer, cobble stone appearance, Pseudpolyps | Non-specific colitis without vasculitis | Salazosulpha-pyridine 1g/d,Azathiop-rine75mg | [6] |
hematochezia | |||||||||
6 | 49F | 5years | ANA positive | Diarrhea | N/A | Emergent operation with | Transmural fibrosis and | Mesalazine | [7] |
anti-dsDNA 234IU/ml | Abdominal pain | a right hemicolectomy was performed. | inflammation with lymphocyte aggregation, but no evidence of vasculitis. | Prednisone 10mg b.i.d. | |||||
Massive bloody stool | |||||||||
7 | 55F | 36years | a high titer of anti-dsDNA antibody (at diagonosis of SLE) a positive result for ANA | Diarrhea | 48 | Longitudinal ulcers, cobble stone appearance, Pseudpolyps | active colitis with noncaceating granulomas without vasculitis | Infliximab | The present case |
Abdominal pain | |||||||||
bloody stool | |||||||||
anal fistula |