Figure 2From: Murine CD4+CD25- cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo CD4 + CD25 - cells up-regulate markers associated with regulatory phenotype. TregPMA cells express the markers CTLA-4 (A), GARP (B), ICOS (C) and OX40 (D) associated with a regulatory phenotype and function. Representative histogram overlays are shown. In red CD4+CD25- T cells at time 0 and in blue TregPMA cells after following PMA/ionomycin/anti-CD3 activation and 5 days in culture.Back to article page