Table 4 Allele frequencies of GNB1 single nucleotide polymorphisms in HCV-1 and HCV-2 infected patients receiving PEG-IFNα-RBV therapy with and without a RVR in a Chinese population in Taiwan
HCV-1 | HCV-2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
SNP ID | RVR (+) (N = 108) N (%) | RVR (−) (N = 157) N (%) | Pvalue | OR (95% CI) | SNP ID | RVR (+) (N = 158) N (%) | RVR (−) (N = 37) N (%) | Pvalue | OR (95% CI) |
rs10907185 | rs10907185 | ||||||||
A allele | 65 (30.0) | 80 (25.5) | 1.26 (0.86, 1.85) | A allele | 88 (27.8) | 16 (21.6) | 1.40 (0.76, 2.56) | ||
G allele | 151 (70.0) | 234 (74.5) | 0.2416 | 1 | G allele | 228 (72.2) | 58 (78.4) | 0.2756 | 1 |
rs6603797 | rs6603797 | ||||||||
C allele | 193 (89.4) | 270 (86.0) | 1.37 (0.80, 2.34) | C allele | 285 (90.2) | 67 (90.5) | 0.96 (0.41, 2.28) | ||
T allele | 23 (10.6) | 44 (14.0) | 0.2521 | 1 | T allele | 31 (9.8) | 7 (9.5) | 0.9270 | 1 |
rs4648727 a | rs4648727 a | ||||||||
A allele | 70 (32.4) | 107 (34.3) | 0.92 (0.64, 1.33) | A allele | 111 (35.1) | 17 (23.6) | 1.75 (0.97, 3.16) | ||
C allele | 146 (67.6) | 205 (65.7) | 0.6515 | 1 | C allele | 205 (64.9) | 55 (76.4) | 0.0607 | 1 |
rs12126768 a | rs12126768 | ||||||||
G allele | 45 (20.8) | 86 (27.6) | 0.69 (0.46, 1.04) | G allele | 75 (23.7) | 16 (21.6) | 1.13 (0.61, 2.08) | ||
T allele | 171 (79.2) | 226 (72.4) | 0.0783 | 1 | T allele | 241 (76.3) | 58 (78.4) | 0.6989 | 1 |