Table 3 Genotype frequencies of GNB1 single nucleotide polymorphisms (SNPs) in HCV-1 and HCV-2 infected patients receiving PEG-IFNα-RBV therapy with and without a RVR in a Chinese population in Taiwan
HCV-1 | HCV-2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
SNP ID | RVR (+) (N = 108) N (%) | RVR (−) (N = 157) N (%) | Pvalue | OR (95% CI) | SNP ID | RVR (+) (N = 158) N (%) | RVR (−) (N = 37) N (%) | Pvalue | OR (95% CI) |
rs10907185 | rs10907185 | ||||||||
A/A | 10 (9.2) | 5 (3.2) | 3.09 (1.00, 9.56) | A/A | 13 (8.3) | 3 (8.1) | 1.25 (0.33, 4.76) | ||
A/G | 45 (41.7) | 70 (44.6) | 0.99 (0.60, 1.66) | A/G | 62 (39.2) | 10 (27.0) | 1.79 (0.80, 4.02) | ||
G/G | 53 (49.1) | 82 (52.2) | 0.1096 | 1 | G/G | 83 (52.5) | 24 (64.9) | 0.3601 | 1 |
A/A + A/G | 55 (50.9) | 75 (47.8) | 0.6137 | 1.13 (0.69, 1.85) | A/A + A/G | 75 (47.5) | 13 (35.1) | 0.1748 | 1.67 (0.79, 3.51) |
rs6603797 | rs6603797 | ||||||||
C/C | 87 (80.5) | 116 (73.9) | 1.13 (0.18, 6.88) | C/C | 129 (81.6) | 31 (83.8) | 2.08 (0.18, 23.69) | ||
C/T | 19 (17.6) | 38 (24.2) | 0.75 (0.12, 4.88) | C/T | 27 (17.1) | 5 (13.5) | 2.70 (0.20, 35.75) | ||
T/T | 2 (1.9) | 3 (1.9) | 0.4332 | 1 | T/T | 2 (1.3) | 1 (2.7) | 0.7216 | 1 |
C/C + C/T | 106 (98.1) | 154 (98.1) | 0.9723 | 1.03 (0.17, 6.29) | C/C + C/T | 156 (98.7) | 36 (97.3) | 0.5227 | 2.17 (0.19, 24.55) |
rs4648727 a | rs4648727 a | ||||||||
A/A | 10 (9.3) | 14 (9.0) | 0.94 (0.38, 2.29) | A/A | 16 (10.1) | 4 (11.1) | 1.46 (0.44, 4.83) | ||
A/C | 50 (46.3) | 79 (50.6) | 0.83 (0.50, 1.39) | A/C | 79 (50.0) | 9 (25.0) | 3.20 (1.39, 7.41) | ||
C/C | 48 (44.4) | 63 (40.4) | 0.7779 | 1 | C/C | 63 (39.9) | 23 (63.9) | 0.0194* | 1 |
A/A + A/C | 60 (55.6) | 93 (59.6) | 0.5112 | 0.86 (0.52, 1.41) | A/A + A/C | 95 (60.1) | 13 (36.1) | 0.0089* | 2.67 (1.26, 5.65) |
rs12126768 a | rs12126768 | ||||||||
G/G | 6 (5.5) | 9 (5.8) | 0.76 (0.26, 2.25) | G/G | 6 (3.8) | 4 (10.8) | 0.42 (0.11, 1.61) | ||
G/T | 33 (30.6) | 68 (43.6) | 0.56 (0.33, 0.94) | G/T | 63 (39.9) | 8 (21.6) | 2.21 (0.94, 5.22) | ||
T/T | 69 (63.9) | 79 (50.6) | 0.0891 | 1 | T/T | 89 (56.3) | 25 (67.6) | 0.0436* | 1 |
G/G + G/T | 39 (36.1) | 77 (49.4) | 0.0330* | 0.58 (0.35, 0.96) | G/G + G/T | 69 (43.7) | 12 (32.4) | 0.2118 | 1.62 (0.76, 3.44) |