Association of genetic variations in GNB1 with response to peginterferon plus ribavirin therapy for chronic hepatitis C in a Chinese population in Taiwan

Table 2 Four single nucleotide polymorphisms in the GNB1 gene in 265 HCV-1 and 195 HCV-2 infected patients receiving PEG-IFNα-RBV therapy with or without a RVR in a Chinese population in Taiwan

SNP	Position inGNB1	Chromosome position^a	Alleles	HCV-1			HCV-2
				HWE (Pvalue)	MAF		HWE (Pvalue)	MAF
				HWE (Pvalue)	RVR (+)	RVR (−)	HWE (Pvalue)	RVR (+)	RVR (−)
rs10907185 (S1)	Intron 7	1733219	A/G	0.2132	0.3009	0.2548	0.465	0.2785	0.2162
rs6603797 (S2)	Intron 2	1765583	C/T	0.5854	0.1065	0.1401	0.4007	0.0981	0.0946
rs4648727 (S3)	Intron 1	1776269	A/C	0.1309	0.3241	0.3429	0.8709	0.3513	0.2361
rs12126768 (S4)	Intron 1	1778090	G/T	0.7439	0.2083	0.2756	1	0.2373	0.2162

Abbreviations: SNP, single nucleotide polymorphism; HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency.
^a Chromosome positions refer to the sequence in the NCBI database (build 37.3).

ISSN: 1471-230X