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Table 1 Characteristics of the subjects

From: Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases

No.

Age

Sex

Liver Diagnosis

HCV genotype

HCV RNA level

IFN

Candida

Oral mucosal lesions

Study group 1/2

Before IFN

colony (n)

2 W after IFN

colony (n)

3 M after IFN

colony (n)

6 M after IFN

colony (n)

end of treatment

colony (n)

6 M after end of treatment

colony (n)

Detection during IFN therapy (at least once)

1

70

F

CH-C

1b

High

Peg-IFN/RBV

−

 

−

 

−

 

−

 

−

 

−

 

−

−

group 2

2

52

M

CH-C

1b

High

Peg-IFN/RBV

+

 

+

 

+

 

+

 

+

 

+

 

+

+

group 1

       

C. albicans

3

C. albicans

1

C. albicans

1

C. albicans

1

C. albicans

1

C. albicans

2

 
                 

C. tropicalis

1

 
       

OLP

 

OLP

 

OLP

 

OLP

 

OLP

 

OLP

  

3

33

F

CH-C

1b

High

Peg-IFN/RBV

+

 

−

 

−

 

−

 

−

 

−

 

−

−

group 2

       

C. albicans

2

           

4

53

F

LC-C

ND (serogroup 2)

Low

IFN beta

−

 

−

 

−

 

−

 

−

 

−

 

−

−

group 2

5

70

F

CH-C

2a

High

Peg-IFN/RBV

+

 

−

 

+

 

+

 

+

 

−

 

+

+

group 1

       

C. albicans

1

  

C. albicans

1

C. albicans

2

C. albicans

2

   
           

C. parapsilosis

1

       
             

angular cheilitis

      

6

60

F

CH-C

2a

High

Peg-IFN/RBV

−

 

−

 

−

 

−

 

−

 

−

 

−

−

group 2

7

57

F

CH-C

1b

High

Peg-IFN/RBV

+

 

−

 

+

 

+

 

+

 

+

 

+

+

group 1

       

C. albicans

2

  

C. albicans

1

C. albicans

1

C. albicans

1

C. albicans

1

 
           

recurrent aphthous stomatitis

 

recurrent aphthous stomatitis

 

recurrent aphthous stomatitis

    

8

58

F

CH-C

1b

High

Peg-IFN/RBV

−

 

−

 

−

 

+

 

−

 

−

 

+

−

group 1

             

C. albicans

1

     

9

25

F

CH-C

1b

High

Peg-IFN/RBV

−

 

−

 

−

 

−

 

−

 

−

 

−

−

group 2

10

54

F

CH-C

1b

High

Peg-IFN/RBV

−

 

−

 

−

 

−

 

−

 

−

 

−

+

group 2

               

OLP

 

OLP

  

11

61

F

CH-C

1b

High

Peg-IFN/RBV

+

 

−

 

+

 

+

 

−

 

−

 

+

+

group 1

       

C. albicans

1

  

C. albicans

1

C. albicans

1

     
           

angular cheilitis

        

12

69

F

CH-C

1b

High

Peg-IFN/RBV

+

 

−

 

+

 

+

 

+

 

+

 

+

+

group 1

       

C. albicans

1

  

C. albicans

1

C. albicans

1

C. albicans

1

C. albicans

1

 
             

angular cheilitis

      

13

60

M

CH-C

1b

High

Peg-IFN/RBV

−

 

−

 

−

 

−

 

−

 

−

 

−

−

group 2

14

62

M

CH-C

1b

Low

Peg-IFN/RBV

−

 

−

 

−

 

−

 

+

 

−

 

+

+

group 1

               

C. lusitaniae

1

   
           

OLP

 

OLP

 

OLP

 

OLP

  

Incidence of Candida or mucosal lesions (%)

 

42.86%

 

7.14%

 

35.71%

 

42.86%

 

35.71%

 

21.43%

 

50.00%

50.00%

 

Total colonies (n)

  

10

 

1

 

6

 

7

 

6

 

5

   

C. albicans (the number of patients)

 

6

 

1

 

5

 

6

 

4

 

3

    

C. parapsilosis (the number of patients)

 

0

 

0

 

1

 

0

 

0

 

0

    

C. lusitaniae (the number of patients)

 

0

 

0

 

0

 

0

 

1

 

0

    

C. tropicalis (the number of patients)

 

0

 

0

 

0

 

0

 

0

 

1

    
  1. HCV, hepatitis C virus; CH-C, chronic hepatitis C; LC-C, liver cirrhosis type C; OLP, oral lichen planus; C., Candida; IFN, interferon; Peg-IFN, pegylated interferon; RBV, ribavirin; M, male; F, female; ND, not detected; −, negative; +, positive.
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BMC Gastroenterology

ISSN: 1471-230X

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