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Table 1 Characteristics of the subjects

From: Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases

No. Age Sex Liver Diagnosis HCV genotype HCV RNA level IFN Candida Oral mucosal lesions Study group 1/2
Before IFN colony (n) 2 W after IFN colony (n) 3 M after IFN colony (n) 6 M after IFN colony (n) end of treatment colony (n) 6 M after end of treatment colony (n) Detection during IFN therapy (at least once)
1 70 F CH-C 1b High Peg-IFN/RBV        group 2
2 52 M CH-C 1b High Peg-IFN/RBV +   +   +   +   +   +   + + group 1
        C. albicans 3 C. albicans 1 C. albicans 1 C. albicans 1 C. albicans 1 C. albicans 2  
                  C. tropicalis 1  
        OLP   OLP   OLP   OLP   OLP   OLP   
3 33 F CH-C 1b High Peg-IFN/RBV +        group 2
        C. albicans 2            
4 53 F LC-C ND (serogroup 2) Low IFN beta        group 2
5 70 F CH-C 2a High Peg-IFN/RBV +    +   +   +    + + group 1
        C. albicans 1    C. albicans 1 C. albicans 2 C. albicans 2    
            C. parapsilosis 1        
              angular cheilitis       
6 60 F CH-C 2a High Peg-IFN/RBV        group 2
7 57 F CH-C 1b High Peg-IFN/RBV +    +   +   +   +   + + group 1
        C. albicans 2    C. albicans 1 C. albicans 1 C. albicans 1 C. albicans 1  
            recurrent aphthous stomatitis   recurrent aphthous stomatitis   recurrent aphthous stomatitis     
8 58 F CH-C 1b High Peg-IFN/RBV     +     + group 1
              C. albicans 1      
9 25 F CH-C 1b High Peg-IFN/RBV        group 2
10 54 F CH-C 1b High Peg-IFN/RBV        + group 2
                OLP   OLP   
11 61 F CH-C 1b High Peg-IFN/RBV +    +   +     + + group 1
        C. albicans 1    C. albicans 1 C. albicans 1      
            angular cheilitis         
12 69 F CH-C 1b High Peg-IFN/RBV +    +   +   +   +   + + group 1
        C. albicans 1    C. albicans 1 C. albicans 1 C. albicans 1 C. albicans 1  
              angular cheilitis       
13 60 M CH-C 1b High Peg-IFN/RBV        group 2
14 62 M CH-C 1b Low Peg-IFN/RBV      +    + + group 1
                C. lusitaniae 1    
            OLP   OLP   OLP   OLP   
Incidence of Candida or mucosal lesions (%)   42.86%   7.14%   35.71%   42.86%   35.71%   21.43%   50.00% 50.00%  
Total colonies (n)    10   1   6   7   6   5    
C. albicans (the number of patients)   6   1   5   6   4   3     
C. parapsilosis (the number of patients)   0   0   1   0   0   0     
C. lusitaniae (the number of patients)   0   0   0   0   1   0     
C. tropicalis (the number of patients)   0   0   0   0   0   1     
  1. HCV, hepatitis C virus; CH-C, chronic hepatitis C; LC-C, liver cirrhosis type C; OLP, oral lichen planus; C., Candida; IFN, interferon; Peg-IFN, pegylated interferon; RBV, ribavirin; M, male; F, female; ND, not detected; −, negative; +, positive.