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Table 1 Clinical, histological and serological parameters in 59 untreated patients with PBC at time of first diagnosis

From: Analysis of the clinical relevance of antimitochondrial antibodies to the β- and γ-subunits of the F1F0-ATPase in patients with primary biliary cirrhosis

Parameters Total Inactive PBC Active PBC
  n = 59 n = 37 n = 22
Females (number) 56 36 20
Males (number) 3 1 2
Biochemical parameters: mean + SD (median)
AP (U/l) (normal < 120) 440 + 374 (309) 344 + 250 (235) 647+519 (537)a)
ASAT (U/l) (normal < 35) 38 + 43 (24) 34 + 48 (20) 46 + 28 (43)b)
ALAT (U/l) (normal < 35) 51 + 56 (26) 43 + 53 (25) 62 + 62 (42)
γGT (U/l) (normal < 50) 145 + 107 (129) 128 + 86 (127) 194 + 146 (164)
bilirubin (mg%) (normal < 1.5) 1,4 + 1,8 (1,0) 0,8 + 0,7 (0,9) 2,3 + 2,8 (1,5)b)
IgG-globulins (mg%) (normal < 1800) 1527 + 477 (1450) 1395 + 603 (1310) 1331 + 733 (1450)
IgM-globulins (mg%) (normal < 280) 373 + 201 (324) 298 + 162 (162) 398 + 290 (427)
Histological stages (number):
PBC I/II 45 37 8
PBC III/IV 14 0 14
Autoantibodies to: number (%)
mitochondria (IFT) 54 (92) 33 (89) 21 (95)
M2 (ELISA) 51 (86) 31 (84) 20 (91)
nuclear dots (sp100; IFT) 14 (24) 9 (24) 5 (23)
nuclear membrane (gp210; IFT) 4 (7) 1 (3) 3 (14)
centromeres 6 (10) 2 (5) 3 (14)
  1. Significance between patients with inactive and active PBC: a) trend with p = 0.08; b) p < 0.05.