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Figure 5 | BMC Gastroenterology

Figure 5

From: A possible involvement of Nrf2-mediated heme oxygenase-1 up-regulation in protective effect of the proton pump inhibitor pantoprazole against indomethacin-induced gastric damage in rats

Figure 5

Pantoprazole prevents to the indomethacin-induced gastric damage through depending on the induction of HO-1. (A) Mean index of indomethacin-induced gastric damages. (B) RT-PCR for HO-1 and ICAM-1 according to group. (C) EMSA for HIF-1α according to group. Indomethacin significantly increased HIF-1α-DNA binding, whereas pantoprazole significantly decreased HIF-1α-DNA binding in a dose-dependent manner.

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BMC Gastroenterology

ISSN: 1471-230X

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