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Table 2 Liver functions and laboratory data at the first presentation of definite NICCD, and non-NICCD patients

From: Neonatal intrahepatic cholestasis caused by citrin deficiency: prevalence and SLC25A13mutations among thai infants

Parameters Definite NICCD (n=5) median (range) Non-NICCD (n=32) median (range) Normal value P-valuea
TB (mg/dL) 7.1 (4.7-9.8) 7.6 (3.5-49.9) 0.2-1.0 0.61
DB (mg/dL) 3.8 (2.6-6.9) 5.9 (1.8-40.1) 0.0-0.7 0.18
ALP (U/L) 1016 (665-3014) 540 (256-1935) 185-555 0.01
GGT (U/L) 160 (127-289) 188 (35-936) 12-123b 0.86
AST (U/L) 144 (62-268) 173 (63-942) 15-37 0.48
ALT (U/L) 61 (49-127) 135 (28-525) 30-65 0.03
AST/ALT ratio 2.1 (1.1-3.3) 1.3 (0.6-5.2) - 0.07
TP (g/L) 51 (38-61) 54 (34-75) 64-82 0.42
Albumin (g/L) 33 (25-37) 35 (17-38) 34-50 0.33
AFP (ng/mL) 60500 (38930 – 60500) (n=4) 22678 (30-60500) (n=9) 88±87c 0.01
Hypoglycemiad 2 (40%) 1 (3.1%) - 0.01
Galactosuria 3/4 (75%) 0   -
Prolonged PTe 2/3 (67%) 6/24 (25%) - 0.14
  1. TB total bilirubin, DB direct bilirubin, ALP alkaline phosphatase, GGT γ-glutamyltransferase, AST aspartate aminotransferase, ALT alanine aminotransferase, TP total protein, AFP alpha-fetoprotein, PT prothrombin time, NA not available.
  2. a Only definite NICCD and non-NICCC groups were compared, and statistical significance if P-value <0.05.
  3. b Normal values for children 1-2 months, 12-123; 2-4 months, 8-90; 4 months-10 years, 5-32 U/L.
  4. c Normal values for children at 3 months, 88±87; 5 months, 46.5±19; 6 months, 12.5±9.8; 8-12 months, 8.5±5.5 ng/mL.
  5. d Hypoglycemia defined as blood glucose <2.5 mmol/L or 45 mg/dL.
  6. e Prolonged PT defined as INR>1.2.