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Table 2 Liver functions and laboratory data at the first presentation of definite NICCD, and non-NICCD patients

From: Neonatal intrahepatic cholestasis caused by citrin deficiency: prevalence and SLC25A13mutations among thai infants

Parameters

Definite NICCD (n=5) median (range)

Non-NICCD (n=32) median (range)

Normal value

P-valuea

TB (mg/dL)

7.1 (4.7-9.8)

7.6 (3.5-49.9)

0.2-1.0

0.61

DB (mg/dL)

3.8 (2.6-6.9)

5.9 (1.8-40.1)

0.0-0.7

0.18

ALP (U/L)

1016 (665-3014)

540 (256-1935)

185-555

0.01

GGT (U/L)

160 (127-289)

188 (35-936)

12-123b

0.86

AST (U/L)

144 (62-268)

173 (63-942)

15-37

0.48

ALT (U/L)

61 (49-127)

135 (28-525)

30-65

0.03

AST/ALT ratio

2.1 (1.1-3.3)

1.3 (0.6-5.2)

-

0.07

TP (g/L)

51 (38-61)

54 (34-75)

64-82

0.42

Albumin (g/L)

33 (25-37)

35 (17-38)

34-50

0.33

AFP (ng/mL)

60500 (38930 – 60500) (n=4)

22678 (30-60500) (n=9)

88±87c

0.01

Hypoglycemiad

2 (40%)

1 (3.1%)

-

0.01

Galactosuria

3/4 (75%)

0

 

-

Prolonged PTe

2/3 (67%)

6/24 (25%)

-

0.14

  1. TB total bilirubin, DB direct bilirubin, ALP alkaline phosphatase, GGT γ-glutamyltransferase, AST aspartate aminotransferase, ALT alanine aminotransferase, TP total protein, AFP alpha-fetoprotein, PT prothrombin time, NA not available.
  2. a Only definite NICCD and non-NICCC groups were compared, and statistical significance if P-value <0.05.
  3. b Normal values for children 1-2 months, 12-123; 2-4 months, 8-90; 4 months-10 years, 5-32 U/L.
  4. c Normal values for children at 3 months, 88±87; 5 months, 46.5±19; 6 months, 12.5±9.8; 8-12 months, 8.5±5.5 ng/mL.
  5. d Hypoglycemia defined as blood glucose <2.5 mmol/L or 45 mg/dL.
  6. e Prolonged PT defined as INR>1.2.