|
Parameters
|
Definite NICCD (n=5) median (range)
|
Non-NICCD (n=32) median (range)
|
Normal value
|
P-valuea
|
|---|
|
TB (mg/dL)
|
7.1 (4.7-9.8)
|
7.6 (3.5-49.9)
|
0.2-1.0
|
0.61
|
|
DB (mg/dL)
|
3.8 (2.6-6.9)
|
5.9 (1.8-40.1)
|
0.0-0.7
|
0.18
|
|
ALP (U/L)
|
1016 (665-3014)
|
540 (256-1935)
|
185-555
|
0.01
|
|
GGT (U/L)
|
160 (127-289)
|
188 (35-936)
|
12-123b
|
0.86
|
|
AST (U/L)
|
144 (62-268)
|
173 (63-942)
|
15-37
|
0.48
|
|
ALT (U/L)
|
61 (49-127)
|
135 (28-525)
|
30-65
|
0.03
|
|
AST/ALT ratio
|
2.1 (1.1-3.3)
|
1.3 (0.6-5.2)
|
-
|
0.07
|
|
TP (g/L)
|
51 (38-61)
|
54 (34-75)
|
64-82
|
0.42
|
|
Albumin (g/L)
|
33 (25-37)
|
35 (17-38)
|
34-50
|
0.33
|
|
AFP (ng/mL)
|
60500 (38930 – 60500) (n=4)
|
22678 (30-60500) (n=9)
|
88±87c
|
0.01
|
|
Hypoglycemiad
|
2 (40%)
|
1 (3.1%)
|
-
|
0.01
|
|
Galactosuria
|
3/4 (75%)
|
0
| |
-
|
|
Prolonged PTe
|
2/3 (67%)
|
6/24 (25%)
|
-
|
0.14
|
-
TB total bilirubin, DB direct bilirubin, ALP alkaline phosphatase, GGT γ-glutamyltransferase, AST aspartate aminotransferase, ALT alanine aminotransferase, TP total protein, AFP alpha-fetoprotein, PT prothrombin time, NA not available.
-
a Only definite NICCD and non-NICCC groups were compared, and statistical significance if P-value <0.05.
-
b Normal values for children 1-2 months, 12-123; 2-4 months, 8-90; 4 months-10 years, 5-32 U/L.
-
c Normal values for children at 3 months, 88±87; 5 months, 46.5±19; 6 months, 12.5±9.8; 8-12 months, 8.5±5.5 ng/mL.
-
d Hypoglycemia defined as blood glucose <2.5 mmol/L or 45 mg/dL.
-
e Prolonged PT defined as INR>1.2.
