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Table 2 Results for binary logistic regression analysis using comorbidities and exposure to drugs in IBS

From: Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study

  IBS patients N = 287 Controls N = 287 OR [95% CI] uncorrected for comorbidities OR [95% CI] corrected for comorbidities OR [95% CI] excluding patients with psychiatric comorbidity OR [95%] excluding patients with RA or arthritis OR [95% CI] excluding patients with GERD/FD
FD or GERD 25.2% 9.8% NA 2.0 [1.1-3.5] 2.8 [1.5-5.2] 2.1 [1.8-3.8] NA
Psychiatric comorbidity 40.4% 3.5% NA 16.6 [7.9-34.8] NA 17.0 [8.0-36.2] 33.3 [11.6-95.5]
Fibromyalgia 4.4% 0% NA NA NA NA NA
Rheumatoid arthritis 6.1% 0% NA NA NA NA NA
PPIs 21.2% 5.2% 2.2 [1.1-5.0] 2.1 [1.1-4.1] 3.0 [1.3-7.0] 3.1 [1.5-6.2] 2.1 [0.8-5.4]
NSAIDs 20.55% 3.8% 3.8 [1.7-8.6] 5.2 [2.5-11.0] 4.1 [1.7-9.6] 5.7 [2.65-12.2] 5.5 [2.3-13.3]
SSRIs 10.84% 2.1% 3.7 [1.3-10.9] 0.9 [0.3-2.7] 6.3 [0.7-56.8] 0.75 [0.25-2.3] 2.8 [0.5-14.7]
Diuretics 5.2% 2.8% 1.0 [0.3-3.6] 1.1 [0.3-3.4] 2.4 [0.7-7.9] 1.4 [0.5-3.7] 2.6 [0.8-9.6]
ACE-I 2.8% 1.4% 1.2 [0.2-4.0] 1.4 [0.3-6.0] 0.9 [0.2-4.4] 1.3 [0.3-5.2] 0.8 [0.1-5.0]
  1. PPIs = proton pump inhibitors PPIs, NSAIDs = non-steroidal anti-inflammatory drugs, SSRIs = selective serotonin reuptake inhibitors, ACE-I = angiotensin-converting enzyme inhibitors, RA = rheumatoid arthritis, GERD = gastroesophageal reflux disease, FD = functional dyspepsia. NA = not applicable.